Patias Naiéle Sartori, Maia Sara Vieira, Ferreira Yasmin Gabriele, de Oliveira Natalhya Letícia Ferreira, Ferrarini Stela Regina, Bomfim Gisele Facholi, Sinhorin Adilson Paulo, Aguiar Danilo Henrique, de Queiroz Eveline Aparecida Isquierdo Fonseca, Sinhorin Valéria Dornelles Gindri
Programa de Pós-Graduação em Biotecnologia e Biodiversidade (Rede Pró-Centro-Oeste), Universidade Federal de Mato Grosso, Sinop 78550-728, MT, Brazil.
Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop 78550-728, MT, Brazil.
Biology (Basel). 2024 Sep 27;13(10):771. doi: 10.3390/biology13100771.
(), popularly known as "almacega" or "white pitch", is widely used in folk medicine due to its antioxidant, anti-inflammatory and healing properties, attributed to its richness in flavonoids and terpenes. Therefore, this study aimed to evaluate the effects of treatment for 28 days with liposomes containing leaf extract in obese animals. Male Wistar rats, subjected to a hypercaloric diet for 8 weeks to induce obesity (hypercaloric chow and water enriched with 30% sucrose, ad libitum), were treated with the plant formulation (1 mg kgday, via gavage) for 28 days. The study investigated morphological, metabolic, redox state, immunological and histological parameters in adipose and liver tissue. Rats were divided into four groups: control (C), liposomes with extract (H), obese (O) and obese treated with liposomes containing extract (OH). The results indicated that the obese group (O) presented weight gain, hepatic steatosis and alterations in metabolic and inflammatory parameters. However, treatment with liposomes (OH) reduced glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine and the lipid profile. In adipose tissue, the OH group showed decreased superoxide dismutase (SOD) activity and increased glutathione S-transferase (GST) activity, in contrast to the effects observed in liver GST. In the analysis of thiobarbituric-acid-reactive substances (TBARS), it was possible to observe an increase in all groups in adipose tissue and in group O in liver tissue, in addition to a reduction in TBARS in group OH in the liver, indicating modulation of oxidative stress. The treatment also increased the concentration of IL-10 and IL-17 in the liver and decreased that of IL-6 in adipose tissue. After 28 days of treatment, these results point to the therapeutic potential of treatment with , not necessarily only against obesity, but also an effect per se of the liposomes, possibly due to the high concentration of flavonoids present in the plant extract.
（），俗称“阿尔马塞加”或“白沥青”，由于其富含黄酮类化合物和萜类化合物而具有抗氧化、抗炎和愈合特性，因此在民间医学中被广泛使用。因此，本研究旨在评估含叶提取物的脂质体对肥胖动物进行28天治疗的效果。雄性Wistar大鼠接受8周的高热量饮食以诱导肥胖（高热量饲料和富含30%蔗糖的水，随意摄取），并用植物制剂（1毫克/千克/天，灌胃）治疗28天。该研究调查了脂肪和肝脏组织中的形态学、代谢、氧化还原状态、免疫学和组织学参数。大鼠分为四组：对照组（C）、含提取物的脂质体组（H）、肥胖组（O）和用含提取物的脂质体治疗的肥胖组（OH）。结果表明，肥胖组（O）出现体重增加、肝脂肪变性以及代谢和炎症参数的改变。然而，脂质体治疗（OH）降低了血糖、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）、肌酐和血脂水平。在脂肪组织中，OH组超氧化物歧化酶（SOD）活性降低，谷胱甘肽S-转移酶（GST）活性增加，这与肝脏GST中观察到的效果相反。在硫代巴比妥酸反应性物质（TBARS）分析中，除了肝脏中OH组的TBARS降低外，所有组的脂肪组织以及O组的肝脏组织中TBARS均增加，表明氧化应激得到调节。该治疗还增加了肝脏中IL-10和IL-17的浓度，并降低了脂肪组织中IL-6的浓度。治疗28天后，这些结果表明（此处原文有缺失，未明确具体物质）治疗具有治疗潜力，不一定仅针对肥胖，而且脂质体本身也有作用，这可能是由于植物提取物中黄酮类化合物的高浓度所致。
