Aldawsari Hibah M, Hanafy Abeer, Labib Gihan S, Badr Jihan M
Z Naturforsch C J Biosci. 2014 Sep-Oct;69(9-10):391-8. doi: 10.5560/znc.2014-0047.
The antihyperglycemic activity of the extracts and preparations of solid lipid nanoparticle suspensions of two mistletoes growing in Saudi Arabia, Plicosepalus acaciae and P. curviflorus, as well as their possible antioxidant effect were investigated in a type 2 diabetic animal model. Type 2 diabetes was induced in adult male Wistar rats by a high-fat diet followed by injection of streptozotocin (STZ). The diabetic rats were treated in parallel with pioglitazone hydrochloride (PIO), non-toxic extracts of P. acaciae and P. curviflorus, as well as three different solid lipid nanoparticle (SLN) suspension formulations prepared from each of the two extracts. Blood glucose level, insulin resistance, oxidative stress parameters, and antioxidant markers were determined. The total extracts of P. acaciae and P. curviflorus as well as the SLN formulations exhibited a significant blood glucose-lowering effect associated with antioxidant effects in the diabetic rats. The SLN preparation with the highest lipid content gave the best result. Reduction of hyperglycemia and insulin resistance in the diabetic rats was, at least partly, due to the antioxidant activities of the extracts and their SLN formulations.
对生长在沙特阿拉伯的两种槲寄生（阿拉伯弯管花和弯花槲寄生）的提取物和固体脂质纳米颗粒悬浮液制剂的抗高血糖活性及其可能的抗氧化作用，在2型糖尿病动物模型中进行了研究。通过高脂饮食诱导成年雄性Wistar大鼠患2型糖尿病，随后注射链脲佐菌素（STZ）。糖尿病大鼠分别用盐酸吡格列酮（PIO）、阿拉伯弯管花和弯花槲寄生的无毒提取物以及由这两种提取物各自制备的三种不同的固体脂质纳米颗粒（SLN）悬浮液制剂进行平行治疗。测定血糖水平、胰岛素抵抗、氧化应激参数和抗氧化标志物。阿拉伯弯管花和弯花槲寄生的总提取物以及SLN制剂在糖尿病大鼠中表现出显著的降血糖作用，并伴有抗氧化作用。脂质含量最高的SLN制剂效果最佳。糖尿病大鼠高血糖和胰岛素抵抗的降低至少部分归因于提取物及其SLN制剂的抗氧化活性。
