Lani R, Mohd Rahim N F, Hassan H, Yaghoobi R, Chang L-Y, AbuBakar S, Zandi K
Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Eur Rev Med Pharmacol Sci. 2015;19(3):461-6.
The Crimean-Congo haemorrhagic fever virus (CCHFV), which is transmitted by the ticks of Hyalomma spp. in general and H. marginatumin particular, can cause severe disease in humans, with mortality rates of 3-30%. Other than from the bites of infected ticks, CCHFV can also be transmitted through contact with patients with the acute phase of infection or contact with blood or tissues from viraemic livestock. Outbreaks of human cases of haemorrhagic manifestations have been documented since 1945 and described in parts of Africa, Asia, Eastern Europe and the Middle East and most recently India in 2011. In addition, serological evidence of the disease has been reported in some countries where no human cases were reported. As regional neighbours China and India have been affected by this virus, this study was conducted to determine the seroprevalence of CCHFV among Orang Asli population of Malaysia as the most at risk people who residing in the deep forests.
A total of 682 serum samples were collected from the Orang Asli population residing in eight states in peninsular Malaysia and analysed for the presence of anti-CCHFV immunoglobulin G (IgG) using a commercial enzyme-linked immunosorbent assay kit.
The study subjects comprised 277 (40.6%) men and 405 (59.4%) women. However, anti-CCHFV IgG was detected in only one female serum sample (0.1%). The presence of anti-CCHFV IgG could not be correlated to age or sex from these findings.
The results of this screening survey showed that the seroprevalence of the anti-CCHFV IgG among Malaysia's Orang Asli population is too low for detection or totally negative compared with that in neighbouring countries, such as India and China.
克里米亚-刚果出血热病毒（CCHFV）一般通过璃眼蜱属蜱虫传播，尤其是边缘璃眼蜱，可导致人类严重疾病，死亡率为3%至30%。除了被感染的蜱虫叮咬外，CCHFV还可通过接触急性期感染患者或接触病毒血症牲畜的血液或组织传播。自1945年以来，已有人类出血热病例暴发的记录，并在非洲、亚洲、东欧和中东部分地区以及最近2011年的印度有所描述。此外，在一些未报告人类病例的国家也有该疾病的血清学证据报告。由于中国和印度这两个地区邻国都受到这种病毒的影响，本研究旨在确定马来西亚原住民（居住在深山老林里的高危人群）中CCHFV的血清流行率。
从居住在马来西亚半岛八个州的原住民中总共采集了682份血清样本，并使用商用酶联免疫吸附测定试剂盒分析抗CCHFV免疫球蛋白G（IgG）的存在情况。
研究对象包括277名男性（40.6%）和405名女性（59.4%）。然而，仅在一份女性血清样本中检测到抗CCHFV IgG（0.1%）。从这些结果来看，抗CCHFV IgG的存在与年龄或性别无关。
这项筛查调查结果显示，与印度和中国等邻国相比，马来西亚原住民中抗CCHFV IgG的血清流行率极低，无法检测到或完全为阴性。
