Remoli Maria Elena, Marchi Antonella, Fortuna Claudia, Benedetti Eleonora, Minelli Giada, Fiorentini Cristiano, Mel Rosanna, Venturi Giulietta, Ciufolini Maria Grazia
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Pathog Dis. 2015 Mar;73(2):1-3. doi: 10.1093/femspd/ftu002. Epub 2014 Dec 4.
Tick-borne encephalitis (TBE) virus infection elicits a life-long lasting protection. However, little is known about the neutralizing antibodies titres following natural infection. In this study, subjects with past TBE disease (n = 62) were analysed for the presence and titre of anti-TBE neutralizing antibodies, and compared with a vaccinated cohort (n = 101). Neutralizing antibody titres were higher in individuals with past TBE and did not show an age-dependent decrease when compared with vaccinees.
蜱传脑炎（TBE）病毒感染可引发终身持久的保护作用。然而，对于自然感染后的中和抗体滴度却知之甚少。在本研究中，对曾患TBE疾病的受试者（n = 62）进行了抗TBE中和抗体的存在情况及滴度分析，并与接种疫苗的队列（n = 101）进行了比较。曾患TBE的个体中和抗体滴度更高，与接种疫苗者相比，未表现出随年龄下降的情况。
