Durrant L G, Jones H, Armitage N C, Baldwin R W
Cancer Research Campaign Laboratory, University of Nottingham, UK.
Br J Cancer. 1989 Oct;60(4):533-7. doi: 10.1038/bjc.1989.308.
The Y haptenic blood group determinant is expressed on the cells of malignant gastrointestinal tumours and on the normal gastrointestinal epithelium of individuals who can secrete blood group antigens. an enzyme-linked immunosorbent assay incorporating the high affinity biotin-avidin interaction was developed to measure the serum levels of antigens bearing the Y hapten in patients with colorectal cancer. The specificity of the assays was between 88 and 93% and the sensitivity in detecting extensive disease was between 24 and 34%. However, up to 67% of patients with local or abdominal recurrent disease secreted antigens expressing the Y hapten, whereas only 30% of patients with overt hepatic metastases secreted a similar antigen. Recognition of antigens bearing the Y hapten may therefore be useful in detecting early local relapse of colorectal cancer when a second operation to excise the recurrence may be possible.
Y半抗原血型决定簇在恶性胃肠道肿瘤细胞以及能分泌血型抗原的个体的正常胃肠道上皮细胞上表达。开发了一种结合高亲和力生物素-抗生物素蛋白相互作用的酶联免疫吸附测定法，以测量结直肠癌患者血清中携带Y半抗原的抗原水平。该测定法的特异性在88%至93%之间，检测广泛疾病的敏感性在24%至34%之间。然而，高达67%的局部或腹部复发疾病患者分泌表达Y半抗原的抗原，而只有30%的显性肝转移患者分泌类似抗原。因此，识别携带Y半抗原的抗原可能有助于检测结直肠癌的早期局部复发，此时可能进行第二次手术切除复发灶。
