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所有抗氧化剂补充剂对预防鼓膜硬化症的潜在效果都相同吗？

Do all antioxidant supplements have the same potential effect on preventing myringosclerosis?

作者信息

Akdagli Seden, Tuzuner Arzu, Demirci Sule, Karadas Hatice, Tulaci Kamil Gökce, Dogan Mehmet, Caylan Refik

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Ministry of Health, Etlik İhtisas Training and Research Hospital, Ankara, Turkey.

Department of Otorhinolaryngology-Head and Neck Surgery, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey.

出版信息

Clin Exp Otorhinolaryngol. 2015 Mar;8(1):1-6. doi: 10.3342/ceo.2015.8.1.1. Epub 2015 Feb 3.

DOI:10.3342/ceo.2015.8.1.1
PMID:25729488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4338085/
Abstract

OBJECTIVES

Myringosclerosis is an irreversible pathological healing mechanism of the tympanic membrane which can result in the formation of sclerotic plaques. Antioxidant treatment is a recognised prevention therapy and coenzyme Q10 (CoQ10), lycopene, and grape seed extract (GSE), were used in this manner.

METHODS

Forty-four Wistar rats were used in this experiment, and, following myringotomies, the animals were randomly divided into four groups. CoQ10, lycopene or GSE was administered orally to the respective groups, starting from the day of surgery. Otomicroscopy examination was performed on the 14th day. All tympanic membrane lesions were evaluated and compared otomicroscopically and histopathologically.

RESULTS

The otomicroscopy and histopathological findings, compared against a control (saline) group, showed the CoQ10, lycopene, and GSE groups had statistically significant differences of degree of sclerosis (P<0.001).

CONCLUSION

CoQ10, lycopene, and GSE were compared against a saline group and their antioxidative and anti-inflammatory effects were similar. The formation of myringosclerotic plagues after experimental myringotomy in rats significantly decreased and diminished after systemic administration of the three different antioxidant supplements.

摘要

目的

鼓膜硬化是鼓膜不可逆的病理愈合机制，可导致硬化斑形成。抗氧化治疗是一种公认的预防疗法，辅酶Q10（CoQ10）、番茄红素和葡萄籽提取物（GSE）已被用于此。

方法

本实验使用44只Wistar大鼠，在鼓膜切开术后，将动物随机分为四组。从手术当天开始，分别对相应组口服CoQ10、番茄红素或GSE。在第14天进行耳显微镜检查。对所有鼓膜病变进行耳显微镜和组织病理学评估及比较。

结果

与对照组（生理盐水）相比，耳显微镜和组织病理学结果显示，CoQ10、番茄红素和GSE组在硬化程度上有统计学显著差异（P<0.001）。

结论

将CoQ10、番茄红素和GSE与生理盐水组进行比较，它们的抗氧化和抗炎作用相似。在大鼠实验性鼓膜切开术后，全身给予三种不同的抗氧化补充剂后，鼓膜硬化斑的形成显著减少并减轻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/cf54b88511c9/ceo-8-1-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/fbac1013686d/ceo-8-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/18cc3a052a67/ceo-8-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/61c51caf9a71/ceo-8-1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/99044d179ea9/ceo-8-1-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/8dd0e41a9e65/ceo-8-1-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/cf54b88511c9/ceo-8-1-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/fbac1013686d/ceo-8-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/18cc3a052a67/ceo-8-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/61c51caf9a71/ceo-8-1-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/99044d179ea9/ceo-8-1-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/8dd0e41a9e65/ceo-8-1-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25bb/4338085/cf54b88511c9/ceo-8-1-g006.jpg

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本文引用的文献

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Effect of caffeic acid phenethyl ester (CAPE) on H₂O₂ induced oxidative and inflammatory responses in human middle ear epithelial cells.咖啡酸苯乙酯（CAPE）对过氧化氢诱导的人中耳上皮细胞氧化和炎症反应的影响。
Int J Pediatr Otorhinolaryngol. 2012 May;76(5):675-9. doi: 10.1016/j.ijporl.2012.01.041. Epub 2012 Feb 25.
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Lycopene and cardiovascular diseases: an update.番茄红素与心血管疾病：最新研究进展。
Curr Med Chem. 2011;18(8):1146-63. doi: 10.2174/092986711795029717.
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Clinical analysis of intratympanic tympanosclerosis: etiology, ossicular chain findings, and hearing results of surgery.
鼓室内鼓室硬化症的临床分析：病因、听骨链表现及手术听力结果
Acta Otolaryngol. 2010 Mar;130(3):370-4. doi: 10.1080/00016480903193429.
4
Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia-reperfusion in the rat.番茄红素对大鼠角叉菜胶诱导的爪肿胀和肝脏缺血再灌注的抗炎作用。
Br J Nutr. 2009 Jul;102(1):126-33. doi: 10.1017/S0007114508137886. Epub 2009 Feb 10.
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