Cotman C W, Geddes J W, Bridges R J, Monaghan D T
Department of Psychobiology, University of California, Irvine 92717.
Neurobiol Aging. 1989 Sep-Oct;10(5):603-5; discussion 618-20. doi: 10.1016/0197-4580(89)90144-9.
The results of several studies now suggest that the density of N-methyl-D-aspartate (NMDA) receptors is maintained in many Alzheimer's disease (AD) cases, although loss of these receptors can occur in specific regions as a consequence of severe neuronal loss. Recent findings demonstrate that there are at least two subtypes of the NMDA receptor which are allosterically regulated. To determine the status of the NMDA receptor in AD, studies are required which will examine the activation state of the NMDA receptor and the properties of subtypes in relation to neuronal density and structure.
现在多项研究结果表明，在许多阿尔茨海默病（AD）病例中，N-甲基-D-天冬氨酸（NMDA）受体的密度得以维持，尽管由于严重的神经元丢失，这些受体在特定区域可能会出现丢失。最近的研究发现表明，NMDA受体至少有两种亚型，它们受到变构调节。为了确定AD中NMDA受体的状态，需要开展相关研究，以检查NMDA受体的激活状态以及各亚型与神经元密度和结构相关的特性。
