代谢型谷氨酸受体信号传导对于视觉皮层中NMDA受体依赖性眼优势可塑性和长时程抑制是必需的。
Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex.
作者信息
Sidorov Michael S, Kaplan Eitan S, Osterweil Emily K, Lindemann Lothar, Bear Mark F
机构信息
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139.
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139
出版信息
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12852-7. doi: 10.1073/pnas.1512878112. Epub 2015 Sep 28.
Abstract
A feature of early postnatal neocortical development is a transient peak in signaling via metabotropic glutamate receptor 5 (mGluR5). In visual cortex, this change coincides with increased sensitivity of excitatory synapses to monocular deprivation (MD). However, loss of visual responsiveness after MD occurs via mechanisms revealed by the study of long-term depression (LTD) of synaptic transmission, which in layer 4 is induced by acute activation of NMDA receptors (NMDARs) rather than mGluR5. Here we report that chronic postnatal down-regulation of mGluR5 signaling produces coordinated impairments in both NMDAR-dependent LTD in vitro and ocular dominance plasticity in vivo. The data suggest that ongoing mGluR5 signaling during a critical period of postnatal development establishes the biochemical conditions that are permissive for activity-dependent sculpting of excitatory synapses via the mechanism of NMDAR-dependent LTD.
摘要
出生后早期新皮层发育的一个特征是通过代谢型谷氨酸受体5（mGluR5）的信号传导出现短暂峰值。在视觉皮层中，这种变化与兴奋性突触对单眼剥夺（MD）的敏感性增加相吻合。然而，MD后视觉反应性的丧失是通过对突触传递的长时程抑制（LTD）研究揭示的机制发生的，在第4层中，这是由NMDA受体（NMDARs）而非mGluR5的急性激活诱导的。我们在此报告，出生后慢性下调mGluR5信号传导会在体外NMDAR依赖性LTD和体内眼优势可塑性方面产生协调性损伤。数据表明，出生后发育关键期持续的mGluR5信号传导建立了生化条件，这些条件允许通过NMDAR依赖性LTD机制对兴奋性突触进行活动依赖性塑造。
相似文献
1
Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex.代谢型谷氨酸受体信号传导对于视觉皮层中NMDA受体依赖性眼优势可塑性和长时程抑制是必需的。
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12852-7. doi: 10.1073/pnas.1512878112. Epub 2015 Sep 28.
2
Brief Novel Visual Experience Fundamentally Changes Synaptic Plasticity in the Mouse Visual Cortex.短暂的新奇视觉体验从根本上改变小鼠视觉皮层的突触可塑性。
J Neurosci. 2017 Sep 27;37(39):9353-9360. doi: 10.1523/JNEUROSCI.0334-17.2017. Epub 2017 Aug 18.
3
Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses.代谢型谷氨酸受体 mGluR5 参与 NMDA 受体依赖性、学习促进的 CA1 突触长时程抑郁。
Cereb Cortex. 2011 Mar;21(3):501-9. doi: 10.1093/cercor/bhq093. Epub 2010 Jun 4.
4
Adenosine A₂A receptors permit mGluR5-evoked tyrosine phosphorylation of NR2B (Tyr1472) in rat hippocampus: a possible key mechanism in NMDA receptor modulation.腺苷A₂A受体使大鼠海马体中mGluR5诱发的NR2B（酪氨酸1472）酪氨酸磷酸化：这可能是NMDA受体调节中的一个关键机制。
J Neurochem. 2015 Nov;135(4):714-26. doi: 10.1111/jnc.13291. Epub 2015 Sep 24.
5
Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice.改变的表面代谢型谷氨酸受体5（mGluR5）动力学引发脆性X智力低下基因1（Fmr1）敲除小鼠的突触N-甲基-D-天冬氨酸受体（NMDAR）功能障碍和认知缺陷。
Nat Commun. 2017 Oct 24;8(1):1103. doi: 10.1038/s41467-017-01191-2.
6
Bidirectional synaptic plasticity induced by conditioned stimulations with different number of pulse at hippocampal CA1 synapses: roles of N-methyl-D-aspartate and metabotropic glutamate receptors.条件刺激引起的海马 CA1 突触中不同脉冲数的双向突触可塑性：N-甲基-D-天冬氨酸和代谢型谷氨酸受体的作用。
Synapse. 2011 Aug;65(8):795-803. doi: 10.1002/syn.20906. Epub 2011 Mar 10.
7
Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex.视觉皮层中眼优势可塑性的双向突触机制。
Philos Trans R Soc Lond B Biol Sci. 2009 Feb 12;364(1515):357-67. doi: 10.1098/rstb.2008.0198.
8
Blockade of GluN2B-Containing NMDA Receptors Prevents Potentiation and Depression of Responses during Ocular Dominance Plasticity.阻断 GluN2B 型 NMDA 受体可防止在眼优势可塑性过程中反应的增强和抑制。
J Neurosci. 2024 Sep 4;44(36):e0021232024. doi: 10.1523/JNEUROSCI.0021-23.2024.
9
Decline of the critical period of visual plasticity is concurrent with the reduction of NR2B subunit of the synaptic NMDA receptor in layer 4.视觉可塑性关键期的衰退与第4层突触N-甲基-D-天冬氨酸受体NR2B亚基的减少同时发生。
J Neurosci. 2003 Jun 15;23(12):5208-18. doi: 10.1523/JNEUROSCI.23-12-05208.2003.
10
Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state.长时程抑制过程中依赖发动蛋白的N-甲基-D-天冬氨酸受体（NMDAR）内吞作用及其对突触状态的依赖性。
BMC Neurosci. 2005 Jul 22;6:48. doi: 10.1186/1471-2202-6-48.
引用本文的文献
1
Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development.代谢型信号在生长发育过程中控制着生长抑素中间神经元的短暂丘脑皮质输入。
Nat Commun. 2024 Jun 26;15(1):5421. doi: 10.1038/s41467-024-49732-w.
2
Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.异突触可塑性与发育中神经元回路的经验依赖性精细化。
Front Neural Circuits. 2021 Dec 7;15:803401. doi: 10.3389/fncir.2021.803401. eCollection 2021.
3
Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS.调控哺乳动物中枢神经系统发育过程中活性依赖型突触修剪的机制。
Nat Rev Neurosci. 2021 Nov;22(11):657-673. doi: 10.1038/s41583-021-00507-y. Epub 2021 Sep 20.
4
Reduced mGluR5 Activity Modulates Mitochondrial Function.代谢型谷氨酸受体5（mGluR5）活性降低调节线粒体功能。
Cells. 2021 Jun 2;10(6):1375. doi: 10.3390/cells10061375.
5
Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.暴露于超重力环境中的大鼠的突触可塑性和新物体识别损伤。
Sci Rep. 2020 Sep 25;10(1):15813. doi: 10.1038/s41598-020-72639-7.
6
Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.拓扑异构酶 3β 敲除小鼠表现出与神经发生和突触可塑性相关的转录和行为障碍。
Nat Commun. 2020 Jun 19;11(1):3143. doi: 10.1038/s41467-020-16884-4.
7
Plasticity of Synaptic Transmission in Human Stem Cell-Derived Neural Networks.人干细胞衍生神经网络中突触传递的可塑性
iScience. 2020 Feb 21;23(2):100829. doi: 10.1016/j.isci.2020.100829. Epub 2020 Jan 9.
8
Distinct Laminar Requirements for NMDA Receptors in Experience-Dependent Visual Cortical Plasticity.NMDA 受体在经验依赖性视觉皮层可塑性中的层状特异性需求。
Cereb Cortex. 2020 Apr 14;30(4):2555-2572. doi: 10.1093/cercor/bhz260.
9
G protein-coupled receptors in acquired epilepsy: Druggability and translatability.获得性癫痫中的 G 蛋白偶联受体：可成药性和可转化性。
Prog Neurobiol. 2019 Dec;183:101682. doi: 10.1016/j.pneurobio.2019.101682. Epub 2019 Aug 24.
10
Early Loss of Vision Results in Extensive Reorganization of Plasticity-Related Receptors and Alterations in Hippocampal Function That Extend Through Adulthood.早期视力丧失导致与可塑性相关的受体广泛重组，并改变海马体功能，这种改变会持续到成年期。
Cereb Cortex. 2019 Feb 1;29(2):892-905. doi: 10.1093/cercor/bhy297.
本文引用的文献
1
Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.视觉识别记忆，表现为长期习惯化，需要 V1 中的突触可塑性。
Nat Neurosci. 2015 Feb;18(2):262-71. doi: 10.1038/nn.3920. Epub 2015 Jan 19.
2
Associative Hebbian synaptic plasticity in primate visual cortex.灵长类视觉皮层的联想海伯突触可塑性。
J Neurosci. 2014 May 28;34(22):7575-9. doi: 10.1523/JNEUROSCI.0983-14.2014.
3
How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex.长时程突触增强和削弱的机制如何在初级视觉皮层中发挥经验依赖性可塑性。
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130284. doi: 10.1098/rstb.2013.0284. Print 2014 Jan 5.
4
Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.慢性药理学 mGlu5 抑制可纠正成年小鼠的脆性 X 。
Neuron. 2012 Apr 12;74(1):49-56. doi: 10.1016/j.neuron.2012.03.009.
5
The pathophysiology of fragile X (and what it teaches us about synapses).脆性 X 症的病理生理学（及其对突触的启示）。
Annu Rev Neurosci. 2012;35:417-43. doi: 10.1146/annurev-neuro-060909-153138. Epub 2012 Apr 5.
6
Critical-period plasticity in the visual cortex.视皮层的关键期可塑性。
Annu Rev Neurosci. 2012;35:309-30. doi: 10.1146/annurev-neuro-061010-113813. Epub 2012 Mar 29.
7
The regulatory role of long-term depression in juvenile and adult mouse ocular dominance plasticity.长时程压抑在幼年和成年小鼠视觉优势可塑性中的调节作用。
Sci Rep. 2011;1:203. doi: 10.1038/srep00203. Epub 2011 Dec 21.
8
Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex.牵拉-推动神经调节 LTP 和 LTD 实现了视觉皮层中双向经验诱导的突触可塑性。
Neuron. 2012 Feb 9;73(3):497-510. doi: 10.1016/j.neuron.2011.11.023.
9
Layer- and cell-type-specific subthreshold and suprathreshold effects of long-term monocular deprivation in rat visual cortex.大鼠视觉皮层中长期单眼剥夺的亚阈和阈上层及细胞类型特异性效应。
J Neurosci. 2011 Nov 23;31(47):17134-48. doi: 10.1523/JNEUROSCI.2951-11.2011.
10
CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.CTEP：一种新型、强效、长效、口服生物利用度的代谢型谷氨酸受体 5 抑制剂。
J Pharmacol Exp Ther. 2011 Nov;339(2):474-86. doi: 10.1124/jpet.111.185660. Epub 2011 Aug 17.
Zotero 插件