Miao Xiangyang, Luo Qingmiao, Qin Xiaoyu
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Gene. 2015 May 15;562(2):188-96. doi: 10.1016/j.gene.2015.02.070. Epub 2015 Feb 27.
Sheep are highly diverse species raised for meat and other agricultural products. The aim of the present study was to investigate the genetic regulators that could control muscle growth and development in different sheep breeds. The study showed that the differentially expressed genes are involved in various cellular activities, such as metabolic cascades, catalytic function and signaling pathway. Many signaling molecules are also found to be differentially expressed, suggesting important roles of signaling pathways contributing to genetic diversity and sheep development. Analysis of miRNAs suggested important roles of miRNAs in controlling muscle differences. This study provided a genome-wide resolution of mRNA and miRNA regulations in muscles from Dorset and Han sheep.
绵羊是用于生产肉类和其他农产品的高度多样化的物种。本研究的目的是调查可控制不同绵羊品种肌肉生长和发育的遗传调节因子。研究表明,差异表达基因参与各种细胞活动,如代谢级联反应、催化功能和信号通路。还发现许多信号分子存在差异表达,表明信号通路在促进遗传多样性和绵羊发育中发挥重要作用。对微小RNA(miRNA)的分析表明miRNA在控制肌肉差异方面具有重要作用。本研究提供了多塞特羊和小尾寒羊肌肉中mRNA和miRNA调控的全基因组分辨率情况。