Whitfield Kyly C, Karakochuk Crystal D, Liu Yazheng, McCann Adrian, Talukder Aminuzzaman, Kroeun Hou, Ward Mary, McNulty Helene, Lynd Larry D, Kitts David D, Li-Chan Eunice C Y, McLean Judy, Green Timothy J
Food, Nutrition, and Health and.
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland; and.
J Nutr. 2015 Mar;145(3):628-33. doi: 10.3945/jn.114.203604. Epub 2015 Jan 7.
Thiamin deficiency in infancy is the underlying cause of beriberi, which can be fatal without rapid treatment. Reports of thiamin deficiency are common in Cambodia; however, population representative data are unavailable. Because B-complex vitamin deficiencies commonly occur in combination, riboflavin was also investigated.
We determined the biomarker status of thiamin and riboflavin in women of childbearing age in rural and urban Cambodia.
We measured thiamin (erythrocyte thiamin diphosphate; TDP) and riboflavin (erythrocyte glutathione reductase activity coefficient; EGRac) status in a representative sample of Cambodian women (aged 20-45 y) in urban Phnom Penh (n = 146) and rural Prey Veng (n = 156), Cambodia, and, for comparison purposes, in a convenience sample of women in urban Vancouver, British Columbia, Canada (n = 49).
Thiamin insufficiency (TDP ≤ 90 nmol/L) was common among both urban (39%) and rural (59%) Cambodian women (P < 0.001), whereas <20% of Vancouver women were thiamin insufficient (P < 0.001). The prevalence of suboptimal and deficient riboflavin status (EGRac ≥ 1.3) was 89%, 92%, and 70% among women in Phnom Penh, Prey Veng, and Vancouver, respectively (P < 0.001).
Suboptimal status of both thiamin and riboflavin were common in Cambodian women, with substantially higher rates among women living in rural Prey Veng than in urban Phnom Penh. Strategies may be needed to improve the thiamin and riboflavin status of women in Cambodia. The unexpected finding of high riboflavin inadequacy status in Vancouver women warrants further investigation.
婴儿期硫胺素缺乏是脚气病的根本原因，若不迅速治疗可能致命。柬埔寨有很多硫胺素缺乏的报告；然而，缺乏具有人群代表性的数据。由于复合维生素B缺乏通常合并出现，因此也对核黄素进行了调查。
我们测定了柬埔寨城乡育龄妇女硫胺素和核黄素的生物标志物状况。
我们测量了柬埔寨金边市（n = 146）和磅湛省农村（n = 156）20至45岁有代表性的柬埔寨妇女样本中的硫胺素（红细胞硫胺素二磷酸；TDP）和核黄素（红细胞谷胱甘肽还原酶活性系数；EGRac）状况，为作比较，还测量了加拿大不列颠哥伦比亚省温哥华市一个方便样本中的妇女（n = 49）。
硫胺素不足（TDP≤90 nmol/L）在柬埔寨城市（39%）和农村（59%）妇女中都很常见（P<0.001），而温哥华只有不到20%的妇女硫胺素不足（P<0.001）。金边、磅湛和温哥华妇女核黄素状况次优和缺乏（EGRac≥1.3）的患病率分别为89%、92%和70%（P<0.001）。
硫胺素和核黄素状况次优在柬埔寨妇女中很常见，生活在磅湛农村的妇女患病率显著高于金边城市妇女。可能需要采取策略来改善柬埔寨妇女的硫胺素和核黄素状况。温哥华妇女核黄素不足状况较高这一意外发现值得进一步调查。
