Rasmussen V M, Borgen A E, Jansen E C, Rotbøll Nielsen P H, Werner M U
Multidisciplinary Pain Center, Neuroscience Center, Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark.
Hyperbaric Unit, Department of Anaesthesia, Head and Orthopedic Center, Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2015 Jul;59(6):749-62. doi: 10.1111/aas.12492. Epub 2015 Mar 3.
Hyperbaric oxygen (HBO2 ) treatment has in animal experiments demonstrated antinociceptive effects. It was hypothesized that these effects would attenuate secondary hyperalgesia areas (SHAs), an expression of central sensitization, after a first-degree thermal injury in humans.
Seventeen healthy volunteers were examined during two sessions using a randomized crossover design. Volunteers were studied during control conditions (ambient pressure, FI O2 = 0.21) and during HBO2 (2.4 standard atmosphere, FI O2 = 1.0, 90 min) conditions in a pressure chamber. Quantitative sensory testing, including assessment of SHAs was performed.
A statistically significant overall attenuation of SHAs was seen during the HBO2 sessions compared with the control-sessions (P = 0.011). In the eight volunteers starting with the HBO2 session, no difference in SHAs compared with control was demonstrated. However, in the nine volunteers starting with the control session, a statistical significant attenuation of SHAs was demonstrated in the HBO2 session (P = 0.004).
The results indicate that HBO2 therapy in humans attenuates central sensitization induced by a thermal skin injury, compared with control. These new and original findings in humans corroborate animal experimental data. The thermal injury model may give impetus to future human neurophysiological studies exploring the central effects of hyperbaric oxygen treatment.
高压氧（HBO2）治疗在动物实验中已显示出抗伤害感受作用。据推测，在人类一度热损伤后，这些作用会减轻作为中枢敏化表现的继发性痛觉过敏区域（SHAs）。
采用随机交叉设计，在两个阶段对17名健康志愿者进行检查。在压力舱中，志愿者分别在对照条件（常压，FiO2 = 0.21）和HBO2条件（2.4标准大气压，FiO2 = 1.0，90分钟）下接受研究。进行了包括SHAs评估在内的定量感觉测试。
与对照阶段相比（P = 0.011），在HBO2阶段观察到SHAs有统计学上显著的总体减轻。在以HBO2阶段开始的8名志愿者中，未显示出与对照相比SHAs有差异。然而，在以对照阶段开始的9名志愿者中，在HBO2阶段显示出SHAs有统计学上显著的减轻（P = 0.004）。
结果表明，与对照相比，人类HBO2治疗可减轻皮肤热损伤诱导的中枢敏化。这些在人类中的新的原创性发现证实了动物实验数据。热损伤模型可能会推动未来探索高压氧治疗中枢效应的人类神经生理学研究。
