Migliaccio Raffaella, Agosta Federica, Possin Katherine L, Canu Elisa, Filippi Massimo, Rabinovici Gil D, Rosen Howard J, Miller Bruce L, Gorno-Tempini Maria Luisa
J Alzheimers Dis. 2015;46(2):351-64. doi: 10.3233/JAD-142292.
The term early-onset Alzheimer's disease (EOAD) identifies patients who meet criteria for AD, but show onset of symptoms before the age of 65. We map progression of gray matter atrophy in EOAD patients compared to late-onset AD (LOAD). T1-weighted MRI scans were obtained at diagnosis and one-year follow-up from 15 EOAD, 10 LOAD, and 38 age-matched controls. Voxel-based and tensor-based morphometry were used, respectively, to assess the baseline and progression of atrophy. At baseline, EOAD patients already showed a widespread atrophy in temporal, parietal, occipital, and frontal cortices. After one year, EOAD had atrophy progression in medial temporal and medial parietal cortices. At baseline, LOAD patients showed atrophy in the medial temporal regions only, and, after one year, an extensive pattern of atrophy progression in the same neocortical cortices of EOAD. Although atrophy mainly involved different lateral neocortical or medial temporal hubs at baseline, it eventually progressed along the same brain default-network regions in both groups. The cortical region showing a significant progression in both groups was the medial precuneus/posterior cingulate.
早发性阿尔茨海默病（EOAD）这一术语用于指符合阿尔茨海默病标准，但在65岁之前出现症状的患者。我们绘制了早发性阿尔茨海默病患者与晚发性阿尔茨海默病（LOAD）患者相比的灰质萎缩进展情况。在诊断时以及一年随访时，对15例早发性阿尔茨海默病患者、10例晚发性阿尔茨海默病患者和38例年龄匹配的对照者进行了T1加权磁共振成像扫描。分别使用基于体素的形态测量法和基于张量的形态测量法来评估萎缩的基线情况和进展。在基线时，早发性阿尔茨海默病患者在颞叶、顶叶、枕叶和额叶皮质已经出现广泛萎缩。一年后，早发性阿尔茨海默病患者在内侧颞叶和内侧顶叶皮质出现萎缩进展。在基线时，晚发性阿尔茨海默病患者仅在内侧颞叶区域出现萎缩，一年后，在早发性阿尔茨海默病患者相同的新皮质区域出现广泛的萎缩进展模式。尽管萎缩在基线时主要累及不同的外侧新皮质或内侧颞叶枢纽，但最终两组均沿着相同的脑默认网络区域进展。两组中显示出显著进展的皮质区域是内侧楔前叶/后扣带回。
