Midwestern University College of Health Sciences, Glendale, AZ, USA.
Banner Alzheimer's Institute, 901 E. Willetta St., Phoenix, AZ, 85006, USA.
Aging Clin Exp Res. 2022 Nov;34(11):2905-2909. doi: 10.1007/s40520-022-02222-9. Epub 2022 Aug 29.
The Alzheimer's Questionnaire (AQ) is an informant-based screening tool with good diagnostic accuracy for Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). The aim of this study is to validate the AQ with AD-associated neuritic plaque (NP) and neurofibrillary tangle (NFT) pathology. Data from 205 prospectively followed autopsy cases clinically classified as AD (n = 90), aMCI (n = 42), or cognitively unimpaired (CU, n = 73) were used. Semi-quantitative measures of NP and NFT pathology were correlated with the AQ, Clinical Dementia Rating Sum of Boxes (CDR-SOB), and the Mini-Mental State Exam (MMSE). The AQ correlated significantly (p < 0.001) with NP load (r = 0.37) and NFT load (r = 0.57). The MMSE and CDR-SOB showed similar correlations with NP load (r = - 0.37, r = 0.35, respectively) and NFT load (r = - 0.58, r = 0.55, respectively). The AQ correlates well with NP and NFT pathology of AD, which provides additional confidence to clinicians using the AQ to screen for AD-related cognitive impairment.
阿尔茨海默病问卷 (AQ) 是一种基于知情者的筛查工具，对阿尔茨海默病 (AD) 和遗忘型轻度认知障碍 (aMCI) 具有良好的诊断准确性。本研究旨在通过 AD 相关神经原纤维缠结 (NFT) 和神经纤维缠结 (NFT) 病理学验证 AQ。使用了 205 例前瞻性随访尸检病例的数据，这些病例临床分类为 AD (n=90)、aMCI (n=42) 或认知正常 (CU，n=73)。NFT 病理学的半定量测量与 AQ、临床痴呆评定量表总和评分 (CDR-SOB) 和简易精神状态检查 (MMSE) 相关。AQ 与 NP 负荷 (r=0.37) 和 NFT 负荷 (r=0.57) 呈显著相关 (p<0.001)。MMSE 和 CDR-SOB 与 NP 负荷 (r=-0.37，r=-0.35) 和 NFT 负荷 (r=-0.58，r=-0.55) 呈相似相关性。AQ 与 AD 的 NP 和 NFT 病理学相关性良好，这为临床医生使用 AQ 筛查 AD 相关认知障碍提供了额外的信心。
