Hemann Brian A, Bimson William F, Taylor Allen J
Medical Corps, United States Army, USA.
Am Heart Hosp J. 2007 Spring;5(2):91-6. doi: 10.1111/j.1541-9215.2007.06350.x.
The concepts of risk assessment and reduction are the cornerstones of preventive cardiology practice. The Framingham Heart Study is a landmark achievement that has provided valuable insights into coronary heart disease risk prediction. Through this cohort study, risk calculators have been generated to predict the risk of cardiac disease in asymptomatic patients. These risk predictors are practical, clinically relevant, and modestly accurate. Their accuracy is somewhat limited in applicability among certain specific populations, however, and some well-known risk factors are not incorporated. These are recognized limitations of the Framingham Risk Score, but it is important to keep in mind that the Framingham Heart Study is an ongoing project and that there are new risk prediction models forthcoming to incorporate additional risk factors. The emergence of subclinical atherosclerosis testing offers promise to refine the assessment of global risk, specifically identifying subjects assessed as intermediate risk by the standard Framingham Risk Score.
风险评估与降低的概念是预防心脏病学实践的基石。弗雷明汉心脏研究是一项具有里程碑意义的成就，它为冠心病风险预测提供了宝贵的见解。通过这项队列研究，已经生成了风险计算器来预测无症状患者患心脏病的风险。这些风险预测指标实用、与临床相关且准确性尚可。然而，它们的准确性在某些特定人群中的适用性有所局限，并且一些知名的风险因素未被纳入。这些是弗雷明汉风险评分公认的局限性，但需要牢记的是，弗雷明汉心脏研究是一个正在进行的项目，并且即将出现新的风险预测模型以纳入更多风险因素。亚临床动脉粥样硬化检测的出现有望改进整体风险评估，特别是识别那些被标准弗雷明汉风险评分评估为中等风险的受试者。
