Pattnaik Lolly, Acharya Laxmikanta
Institute of Medical Sciences and SUM Hospital, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
Centre of Biotechnology, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
Life Sci. 2015 May 1;128:47-54. doi: 10.1016/j.lfs.2015.01.040. Epub 2015 Mar 3.
Allergic conjunctivitis presents as a spectrum of different clinical entities, such as perennial allergic conjunctivitis, seasonal allergic conjunctivitis, atopic keratoconjunctivitis and vernal keratoconjunctivitis. Vernal keratoconjunctivitis (VKC) is a disorder that is often associated with allergens and is seen during the spring season. Herein, we focused on vernal keratoconjunctivitis (VKC) and reviewed its epidemiology, clinical presentations, ocular associations, available treatment options, and the progressive understanding of its histopathological features; we have also systematically elaborated on the various studies on proteomics. Initial theories of a solely IgE-mediated mechanism have been replaced by those considering IgE and non-IgE mechanisms. Developments in basic and clinical research will open novel diagnostic approaches for the early detection and cure of the disease.
过敏性结膜炎表现为一系列不同的临床病症，如常年性过敏性结膜炎、季节性过敏性结膜炎、特应性角结膜炎和春季角结膜炎。春季角结膜炎（VKC）是一种常与变应原相关的病症，在春季出现。在此，我们聚焦于春季角结膜炎（VKC），回顾了其流行病学、临床表现、眼部相关情况、可用的治疗选择以及对其组织病理学特征的逐步认识；我们还系统阐述了蛋白质组学的各项研究。最初仅由IgE介导机制的理论已被考虑IgE和非IgE机制的理论所取代。基础研究和临床研究的进展将为该疾病的早期检测和治愈开辟新的诊断方法。
