一株产新德里金属β-内酰胺酶-5（NDM-5）的多重耐药大肠杆菌分离株的基因组序列草图
Draft Genome Sequence of a New Delhi Metallo-β-Lactamase-5 (NDM-5)-Producing Multidrug-Resistant Escherichia coli Isolate.
作者信息
de Man Tom J B, Perry K Allison, Avillan Johannetsy J, Rasheed J Kamile, Limbago Brandi M
机构信息
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Genome Announc. 2015 Mar 5;3(2):e00017-15. doi: 10.1128/genomeA.00017-15.
Abstract
A multidrug-resistant Escherichia coli isolate from an abdominal lesion displayed resistance to all β-lactams tested, including carbapenems, in addition to macrolides, fluoroquinolones, and tetracycline. Sequence analyses demonstrated the presence of blaNDM-5 in addition to at least 13 genes and 6 efflux pumps associated with antibiotic resistance.
摘要
从一例腹部病变中分离出的一株多重耐药性大肠杆菌，除了对大环内酯类、氟喹诺酮类和四环素耐药外，对所有测试的β-内酰胺类药物（包括碳青霉烯类）均耐药。序列分析表明，除了至少13个与抗生素耐药相关的基因和6个外排泵外，还存在blaNDM-5基因。
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