School of Chemistry and Chemical Engineering, Queen's University, Belfast BT9 5AG, Northern Ireland.
J Am Chem Soc. 2015 Mar 25;137(11):3763-6. doi: 10.1021/jacs.5b00665. Epub 2015 Mar 17.
Genetically engineered bacteria and reactive DNA networks detect edges of objects, as done in our retinas and as also found within computer vision. We now demonstrate that simple molecular logic systems (a combination of a pH sensor, a photo acid generator, and a pH buffer spread on paper) without any organization can achieve this relatively complex computational goal with good fidelity. This causes a jump in the complexity achievable by molecular logic-based computation and extends its applicability. The molecular species involved in light dose-driven "off-on-off" fluorescence is diverted in the "on" state by proton diffusion from irradiated to unirradiated regions where it escapes a strong quencher, thus visualizing the edge of a mask.
基因工程细菌和反应性 DNA 网络可以检测物体的边缘，就像我们的视网膜和计算机视觉中所做的那样。我们现在证明，简单的分子逻辑系统（由 pH 传感器、光酸发生器和分布在纸上的 pH 缓冲剂组成）无需任何组织就可以很好地实现这一相对复杂的计算目标。这使得基于分子逻辑的计算能够实现的复杂性跃升到一个新的水平，并扩展了其适用性。在光剂量驱动的“开-关-开”荧光中，涉及的分子物种在“开”状态下被质子扩散从辐照区转移到未辐照区，在那里它逃脱了强猝灭剂，从而可视化了掩模的边缘。
