Lorente-Cebrián Silvia, Costa André G V, Navas-Carretero Santiago, Zabala María, Laiglesia Laura M, Martínez J Alfredo, Moreno-Aliaga María J
Department of Nutrition, Food Science and Physiology and Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain.
J Physiol Biochem. 2015 Jun;71(2):341-9. doi: 10.1007/s13105-015-0395-y. Epub 2015 Mar 11.
Inflammation is involved in the pathophysiology of many chronic diseases, such as rheumatoid arthritis and neurodegenerative diseases. Several studies have evidenced important anti-inflammatory and immunomodulatory properties of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs). This review illustrates current knowledge about the efficacy of n-3 LC-PUFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), particularly) in preventing and/or treating several chronic inflammatory conditions (inflammatory bowel diseases and rheumatoid arthritis) as well as their potential benefits on neurodegenerative diseases. It is well established that n-3 LC-PUFAs are substrates for synthesis of novel series of lipid mediators (e.g., resolvins, protectins, and maresins) with potent anti-inflammatory and pro-resolving properties, which have been proposed to partly mediate the protective and beneficial actions of n-3 LC-PUFAs. Here, we briefly summarize current knowledge from preclinical studies analyzing the actions of EPA- and DHA-derived resolvins and protectins on pathophysiological models of rheumatoid arthritis, Alzheimer, and irritable bowel syndrome.
炎症参与了许多慢性疾病的病理生理过程，如类风湿性关节炎和神经退行性疾病。多项研究证实了ω-3长链多不饱和脂肪酸（n-3 LC-PUFAs）具有重要的抗炎和免疫调节特性。本综述阐述了关于n-3 LC-PUFAs（特别是二十碳五烯酸（EPA）和二十二碳六烯酸（DHA））在预防和/或治疗几种慢性炎症性疾病（炎症性肠病和类风湿性关节炎）方面的疗效以及它们对神经退行性疾病潜在益处的现有知识。众所周知，n-3 LC-PUFAs是合成一系列具有强大抗炎和促消退特性的新型脂质介质（如消退素、保护素和maresin）的底物，有人提出这些介质部分介导了n-3 LC-PUFAs的保护和有益作用。在此，我们简要总结临床前研究的现有知识，这些研究分析了源自EPA和DHA的消退素和保护素对类风湿性关节炎、阿尔茨海默病和肠易激综合征病理生理模型的作用。
