Schröder T, Hubold C, Muck P, Lehnert H, Haas C S
Department of Medicine I, Campus Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany.
Neth J Med. 2015 Feb;73(2):82-5.
Hypokalaemic hypertension is the classical presentation of primary hyperaldosteronism but may also result from other mineralocorticoid activity, such as liquorice ingestion. Onset of hypertension as well as serum renin and aldosterone levels are central for the diagnosis. Liquorice ingestion has been reported to induce hypertension, hypokalaemia and metabolic alkalosis due to inhibition of the enzyme 11-β-hydroxy steroiddehydrogenase 2. Here, we report the case of a hypertensive emergency with acute visual impairment due to hypertensive retinopathy in clear conjunction with a considerable consumption of liquorice.
低钾血症性高血压是原发性醛固酮增多症的典型表现,但也可能由其他盐皮质激素活性引起,如摄入甘草。高血压的发作以及血清肾素和醛固酮水平对诊断至关重要。据报道,摄入甘草会因抑制11-β-羟基类固醇脱氢酶2而导致高血压、低钾血症和代谢性碱中毒。在此,我们报告一例因高血压性视网膜病变导致急性视力损害的高血压急症病例,该病例与大量食用甘草明显相关。