Mohammadi V, Khalili M, Eghtesadi S, Dehghani S, Jazayeri S, Aghababaee S K, Sabour H, Saberi H, Eghtesadi M, Gohari M R
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Neurosciences Research Center, Tabriz University of Medical Science, Tabriz, Iran.
Spinal Cord. 2015 Aug;53(8):621-4. doi: 10.1038/sc.2015.35. Epub 2015 Mar 10.
A randomized, double-blind, placebo-controlled clinical trial.
To assess the effect of alpha-lipoic acid (ALA) supplementation on IL-6, hs-CRP, FBS, anthropometric indices, food intake and blood pressure in male patients with chronic spinal cord injury (SCI).
Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fifty-eight men with chronic SCI participated in the study. Participants were divided in two groups: one group received 600 mg of supplemental ALA (n=28) and the other group received placebo (n=30) for 12 weeks. At the beginning and end of the study, biochemical parameters, anthropometric indices, blood pressure and dietary intakes were measured. Dietary intake was measured using N4 software, and statistical analyses were carried out using SPSS16.
No significant reduction was found in IL-6 (P=0.97) and hs-CRP levels (P=0.23). There was significant reduction in fasting blood sugar (P=0.001), body weight (P=0.001), BMI (P=0.001), waist circumference (P=0.001) and blood pressure (P=0.001). Dietary intake was significantly reduced, including fat (P=0.001), carbohydrate (P=0.001), protein (P=0.002) and energy intakes (P=0.001).
Lipoic acid supplementation had no significant effect on the measured inflammatory markers but it reduces fasting blood sugar, anthropometric parameters, food intake and blood pressure in men with chronic SCI.
一项随机、双盲、安慰剂对照临床试验。
评估补充α-硫辛酸（ALA）对慢性脊髓损伤（SCI）男性患者白细胞介素-6（IL-6）、高敏C反应蛋白（hs-CRP）、空腹血糖（FBS）、人体测量指标、食物摄入量和血压的影响。
伊朗德黑兰医科大学伊玛目霍梅尼医院。
58名慢性SCI男性患者参与研究。参与者分为两组：一组接受600毫克补充ALA（n = 28），另一组接受安慰剂（n = 30），为期12周。在研究开始和结束时，测量生化参数、人体测量指标、血压和饮食摄入量。使用N4软件测量饮食摄入量，并使用SPSS16进行统计分析。
IL-6（P = 0.97）和hs-CRP水平（P = 0.23）未发现显著降低。空腹血糖（P = 0.001）、体重（P = 0.001）、体重指数（BMI，P = 0.001）、腰围（P = 0.001）和血压（P = 0.001）有显著降低。饮食摄入量显著减少，包括脂肪（P = 0.001）、碳水化合物（P = 0.001）、蛋白质（P = 0.002）和能量摄入量（P = 0.001）。
补充硫辛酸对所测炎症标志物无显著影响，但可降低慢性SCI男性患者的空腹血糖、人体测量参数、食物摄入量和血压。
