Mohammadi Vida, Khorvash Fariborz, Feizi Awat, Askari Gholamreza
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2018 Apr 5;9:34. doi: 10.4103/ijpvm.IJPVM_32_17. eCollection 2018.
Stroke as a devastating condition is one of the major causes of death worldwide. It is accountable for long time disability with high personal and social cost in adults. There are several risk factors for stroke such as diabetes and hypertension. Alpha-lipoic acid (ALA) as an antioxidant can be a risk modifier in these patients. We designed this trial to scrutinize the possible effects of ALA consumption on some cardiovascular risk factors in patients experienced stroke.
In this randomized, double-blind, placebo-controlled clinical trial, 67 patients experienced stroke were randomly allocated into two groups (taking a 600 mg ALA supplement or placebo daily for 12 weeks). Fasting blood sugar (FBS), fasting insulin and systolic (SBP), and diastolic blood pressure (DBP) were measured before and after intervention in this study. Statistical analyses were performed using SPSS version 16 (SPSS Inc., Chicago, IL, USA) software.
Primary features were similar in the intervention and placebo groups ( > 0.05). After the intervention period, SBP ( < 0.001), DBP ( < 0.001) and FBS ( < 0.001) reduced in ALA group compared with placebo group, significantly. No significant change was seen in insulin level ( = 0.82).
Results of this trial indicated that 12 weeks supplementation with 600 mg ALA has beneficial effects on SBP, DBP, and FBS but has no effect on insulin level.
中风作为一种毁灭性疾病，是全球主要死因之一。它导致成年人长期残疾，个人和社会成本高昂。中风有多种风险因素，如糖尿病和高血压。α-硫辛酸（ALA）作为一种抗氧化剂，可能是这些患者的风险调节剂。我们设计了这项试验，以研究服用ALA对中风患者某些心血管风险因素的可能影响。
在这项随机、双盲、安慰剂对照的临床试验中，67名中风患者被随机分为两组（每天服用600毫克ALA补充剂或安慰剂，持续12周）。本研究在干预前后测量空腹血糖（FBS）、空腹胰岛素、收缩压（SBP）和舒张压（DBP）。使用SPSS 16版（美国伊利诺伊州芝加哥SPSS公司）软件进行统计分析。
干预组和安慰剂组的主要特征相似（P>0.05）。干预期后，与安慰剂组相比，ALA组的SBP（P<0.001）、DBP（P<0.001）和FBS（P<0.001）显著降低。胰岛素水平无显著变化（P=0.82）。
该试验结果表明，600毫克ALA补充剂服用12周对SBP、DBP和FBS有有益影响，但对胰岛素水平无影响。
