He L, Dang L, Zhou J, Bai J, Li Y-Z
Department of Dermatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Laboratory of Medical Genetics, Harbin Medical University, Harbin, China.
Clin Exp Dermatol. 2015 Jul;40(5):556-63. doi: 10.1111/ced.12550. Epub 2015 Mar 8.
Psoriasis involves a multifaceted interplay of keratinocytes, blood vessels, immune system mediators and expressed genes.
To determine whether genetic polymorphisms in the angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2) and caspase-5 (CASP5) genes are associated with an increased risk of developing psoriasis vulgaris (PV) in a Han population in northeastern China.
We analysed single nucleotide polymorphisms of ANGPT1 (rs2507800, rs1954727 and rs1010824), ANGPT2 (rs3739390, rs2442598 and rs1868554) and caspase-5 (rs507879, rs518604 and rs523104) in 343 patients with PV and 347 healthy controls (HCs) by the SNaPshot method, and evaluated the risk for psoriasis conferred by the individual polymorphisms and haplotypes.
The rs2442598 polymorphism of ANGPT2 was significantly associated with PV. The CT+TT genotype was present at an increased frequency in patients with PV (adjusted OR = 1.45, 95% CI 1.04-2.03, P = 0.03). However, the distribution of the other genotypes (rs2507800, rs1954727 and rs1010824 of ANGPT1; rs3739390 and rs1868554 of ANGPT2; and rs507879, rs518604 and rs523104 of caspase-5) was not significantly different between patients with PV and the HCs. Furthermore, none of the genes in the haplotype-based analysis showed any association with psoriasis risk.
Our data suggest that ANGPT2 variants may be involved in PV risk in a Han population in northeastern China.
银屑病涉及角质形成细胞、血管、免疫系统介质和表达基因之间的多方面相互作用。
确定血管生成素-1（ANGPT1）、血管生成素-2（ANGPT2）和半胱天冬酶-5（CASP5）基因的遗传多态性是否与中国东北地区汉族人群寻常型银屑病（PV）发病风险增加相关。
我们采用SNaPshot方法分析了343例PV患者和347例健康对照（HCs）中ANGPT1（rs2507800、rs1954727和rs1010824）、ANGPT2（rs3739390、rs2442598和rs1868554）和半胱天冬酶-5（rs507879、rs518604和rs523104）的单核苷酸多态性，并评估了个体多态性和单倍型赋予银屑病的风险。
ANGPT2的rs2442598多态性与PV显著相关。PV患者中CT+TT基因型的出现频率增加（校正OR = 1.45，95%CI 1.04 - 2.03，P = 0.03）。然而，PV患者和HCs之间其他基因型（ANGPT1的rs2507800、rs1954727和rs1010824；ANGPT2的rs3739390和rs1868554；半胱天冬酶-5的rs507879、rs518604和rs523104）的分布没有显著差异。此外，基于单倍型分析的任何基因均未显示与银屑病风险有任何关联。
我们的数据表明，ANGPT2变异可能与中国东北地区汉族人群的PV风险有关。
