Department of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
School of Medicine, China Medical University, Taichung, Taiwan.
Int J Med Sci. 2019 Jan 1;16(2):331-336. doi: 10.7150/ijms.30582. eCollection 2019.
The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). Between 2016 and 2018, we recruited 335 RA patients and 700 control participants. Comparative genotyping for SNPs rs2442598, rs734701, rs1823375 and rs12674822 was performed. We found that when compared with the subjects with the A/A genotype of SNP rs2442598, the subjects with the T/T genotype were 1.78 times likely to develop RA. The subjects with C/C genotype of SNP rs734701 were 0.53 times likely to develop RA than the subjects with TT genotype, suggesting the protective effect. The subjects with G/G genotype of SNP rs1823375 were 1.77 times likely to develop RA than the subjects with C/C genotype. The subjects with A/C and C/C genotype of SNP rs11137037 were 1.65 and 2.04 times likely to develop RA than the subjects with A/A genotype. The subjects with G/T and T/T genotype of SNP rs12674822 were 2.42 and 2.25 times likely to develop RA than the subjects with G/G genotype. The T allele over rs734701 can lead to higher serum erythrocyte sedimentation rate level ( = 0.006). The A allele over rs11137037 was associated with longer duration between disease onset and blood sampling ( = 0.003). Our study suggested that Ang2 might be a diagnostic marker and therapeutic target for RA therapy. Therapeutic agents that directly or indirectly modulate the activity of Ang2 may be the promising modalities for RA treatment.
血管生成素 2 (Ang2) 基因编码血管生成因子，Ang2 基因的多态性可预测多种人类疾病的风险。我们想研究 Ang2 基因的单核苷酸多态性 (SNP) 是否可预测类风湿关节炎 (RA) 的风险。在 2016 年至 2018 年间，我们招募了 335 名 RA 患者和 700 名对照参与者。对 SNPs rs2442598、rs734701、rs1823375 和 rs12674822 进行比较基因型分析。我们发现，与 SNP rs2442598 的 A/A 基因型相比，T/T 基因型发生 RA 的风险增加 1.78 倍。SNP rs734701 的 C/C 基因型发生 RA 的风险比 TT 基因型低 0.53 倍，提示存在保护作用。SNP rs1823375 的 G/G 基因型发生 RA 的风险比 C/C 基因型高 1.77 倍。SNP rs11137037 的 A/C 和 C/C 基因型发生 RA 的风险比 A/A 基因型高 1.65 和 2.04 倍。SNP rs12674822 的 G/T 和 T/T 基因型发生 RA 的风险比 G/G 基因型高 2.42 和 2.25 倍。rs734701 的 T 等位基因可导致更高的红细胞沉降率水平（ = 0.006）。rs11137037 的 A 等位基因与疾病发病至采血时间间隔较长相关（ = 0.003）。本研究提示 Ang2 可能是 RA 治疗的诊断标志物和治疗靶点。直接或间接调节 Ang2 活性的治疗剂可能是 RA 治疗的有前途方法。
