脂肪量和肥胖相关基因FTO rs9939609多态性与儿童青少年肥胖风险的关联：一项荟萃分析。

Association of fat-mass and obesity-associated gene FTO rs9939609 polymorphism with the risk of obesity among children and adolescents: a meta-analysis.

作者信息

Quan L-L, Wang H, Tian Y, Mu X, Zhang Y, Tao K

机构信息

Department of Plastic Surgery, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China.

出版信息

Eur Rev Med Pharmacol Sci. 2015 Feb;19(4):614-23.

PMID:25753879

Abstract

OBJECTIVE

To elucidate the association of fat-mass and obesity-associated gene (FTO) rs9939609 polymorphism with obesity among children and adolescents.

METHODS

A literature search was conducted in PubMed, MEDLINE, Springer, and Google scholar to identify eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used for four models: co-dominant model (AA vs. TT, AT vs. TT), dominant model (AA + AT vs. TT), recessive model (AA vs. AT + TT), and allelic model (A vs. T). Subgroup analyses stratified by ethnicity (Caucasian, others) and participants (children, children and adolescents) were assessed under allelic model. The heterogeneity and publication bias were examined.

RESULTS

This meta-analysis included 12 eligible studies consisting 5,000 cases and 9,853 controls. The results revealed that FTO rs9939609 polymorphism was significantly associated with the increased risk of obesity in co-dominant model (AA vs. TT: OR = 1.91, 95% CI: 1.47-2.48, p < 0.01; AT vs. TT: OR = 1.18, 95% CI: 1.02-1.38, p = 0.03), dominant model (AA + AT vs. TT: OR = 1.47, 95% CI: 1.35-1.59, p < 0.01), recessive model (AA vs. AT + TT: OR = 1.79, 95% CI: 1.47-2.17, p < 0.01), and allelic model (A vs. T: OR = 1.39, 95% CI: 1.22-1.58, p < 0.01). Similar results were obtained for the subgroup analyses stratified by ethnicity and participants under allelic model.

CONCLUSIONS

FTO rs9939609 polymorphism is associated with the increased risk of obesity among children and adolescents, especially the homozygous carriers.

摘要

目的

阐明脂肪量和肥胖相关基因（FTO）rs9939609多态性与儿童及青少年肥胖之间的关联。

方法

在PubMed、MEDLINE、Springer和谷歌学术中进行文献检索，以确定符合条件的研究。合并的比值比（OR）及95%置信区间（CI）用于四种模型：共显性模型（AA与TT相比，AT与TT相比）、显性模型（AA + AT与TT相比）、隐性模型（AA与AT + TT相比）以及等位基因模型（A与T相比）。在等位基因模型下，对按种族（白种人、其他）和参与者（儿童、儿童及青少年）分层的亚组分析进行评估。检查异质性和发表偏倚。

结果

该荟萃分析纳入了12项符合条件的研究，包括5000例病例和9853例对照。结果显示，FTO rs9939609多态性在共显性模型（AA与TT相比：OR = 1.91，95% CI：1.47 - 2.48，p < 0.01；AT与TT相比：OR = 1.18，95% CI：1.02 - 1.38，p = 0.03）、显性模型（AA + AT与TT相比：OR = 1.47，95% CI：1.35 - 1.59，p < 0.01）、隐性模型（AA与AT + TT相比：OR = 1.79，95% CI：1.47 - 2.17，p < 0.01）和等位基因模型（A与T相比：OR = 1.39，95% CI：1.22 - 1.58，p < 0.01）中均与肥胖风险增加显著相关。在等位基因模型下按种族和参与者分层的亚组分析也获得了类似结果。