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秘鲁高海拔地区每日生物质燃料烟雾暴露与血压之间的关系。

Relationship between daily exposure to biomass fuel smoke and blood pressure in high-altitude Peru.

作者信息

Burroughs Peña Melissa, Romero Karina M, Velazquez Eric J, Davila-Roman Victor G, Gilman Robert H, Wise Robert A, Miranda J Jaime, Checkley William

机构信息

From the Division of Cardiology, Department of Medicine and Duke Clinical Research Institute, Duke University, Durham, NC (M.B.P., E.J.V.); Biomedical Research Unit, A.B. PRISMA, Lima, Peru (K.M.R.); Division of Cardiology, Department of Medicine, Washington University, St. Louis, MO (V.G.D.-R.); Program in Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health (R.H.G.) and Division of Pulmonary and Critical Care Medicine, School of Medicine (R.A.W., W.C.), Johns Hopkins University, Baltimore, MD; and CRONICAS Center of Excellence in Chronic Diseases (R.H.G., J.J.M., W.C.) and Department of Medicine (J.J.M.), Universidad Peruana Cayetano Heredia, Lima, Peru.

出版信息

Hypertension. 2015 May;65(5):1134-40. doi: 10.1161/HYPERTENSIONAHA.114.04840. Epub 2015 Mar 9.

Abstract

Household air pollution from biomass fuel use affects 3 billion people worldwide; however, few studies have examined the relationship between biomass fuel use and blood pressure. We sought to determine if daily biomass fuel use was associated with elevated blood pressure in high altitude Peru and if this relationship was affected by lung function. We analyzed baseline information from a population-based cohort study of adults aged ≥ 35 years in Puno, Peru. Daily biomass fuel use was self-reported. We used multivariable regression models to examine the relationship between daily exposure to biomass fuel smoke and blood pressure outcomes. Interactions with sex and quartiles of forced vital capacity were conducted to evaluate for effect modification. Data from 1004 individuals (mean age, 55.3 years; 51.7% women) were included. We found an association between biomass fuel use with both prehypertension (adjusted relative risk ratio, 5.0; 95% confidence interval, 2.6-9.9) and hypertension (adjusted relative risk ratio, 3.5; 95% confidence interval, 1.7-7.0). Biomass fuel users had a higher systolic blood pressure (7.0 mm Hg; 95% confidence interval, 4.4-9.6) and a higher diastolic blood pressure (5.9 mm Hg; 95% confidence interval, 4.2-7.6) when compared with nonusers. We did not find interaction effects between daily biomass fuel use and sex or percent predicted forced vital capacity for either systolic blood pressure or diastolic blood pressure. Biomass fuel use was associated with a higher likelihood of having hypertension and higher blood pressure in Peru. Reducing exposure to household air pollution from biomass fuel use represents an opportunity for cardiovascular prevention.

摘要

使用生物质燃料造成的家庭空气污染影响着全球30亿人;然而,很少有研究探讨生物质燃料使用与血压之间的关系。我们试图确定在秘鲁高海拔地区,日常使用生物质燃料是否与血压升高有关,以及这种关系是否受肺功能影响。我们分析了秘鲁普诺一项针对≥35岁成年人的基于人群的队列研究的基线信息。日常生物质燃料使用情况通过自我报告获得。我们使用多变量回归模型来研究日常接触生物质燃料烟雾与血压结果之间的关系。与性别和用力肺活量四分位数进行交互分析,以评估效应修正情况。纳入了1004名个体的数据(平均年龄55.3岁;51.7%为女性)。我们发现生物质燃料使用与高血压前期(调整后的相对风险比为5.0;95%置信区间为2.6 - 9.9)和高血压(调整后的相对风险比为3.5;95%置信区间为1.7 - 7.0)均有关联。与不使用生物质燃料的人相比,使用生物质燃料的人收缩压更高(7.0毫米汞柱;95%置信区间为4.4 - 9.6),舒张压也更高(5.9毫米汞柱;95%置信区间为4.2 - 7.6)。对于收缩压或舒张压,我们未发现日常生物质燃料使用与性别或预测用力肺活量百分比之间存在交互作用。在秘鲁,生物质燃料使用与患高血压的可能性增加及血压升高有关。减少因使用生物质燃料造成的家庭空气污染暴露是心血管疾病预防的一个契机。

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