人类癌基因的激活机制。
Mechanism of activation of a human oncogene.
作者信息
Tabin C J, Bradley S M, Bargmann C I, Weinberg R A, Papageorge A G, Scolnick E M, Dhar R, Lowy D R, Chang E H
出版信息
Nature. 1982 Nov 11;300(5888):143-9. doi: 10.1038/300143a0.
DOI:10.1038/300143a0
PMID:6290897
Abstract
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.
摘要
人类EJ膀胱癌细胞系的癌基因是通过细胞原癌基因的改变产生的。本文展示了一些实验，这些实验定位了导致癌基因激活的遗传损伤。该损伤对癌基因的表达水平没有影响。相反，它影响癌基因编码蛋白的结构。
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