Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, Indiana 47405, United States.
J Am Chem Soc. 2015 Mar 18;137(10):3482-5. doi: 10.1021/jacs.5b00563. Epub 2015 Mar 10.
Catalytic enantioselective [2 + 2] cycloadditions between allenoates and alkenes is disclosed. The method functions well for a variety of alkenes, and the products are generated with excellent levels of enantioselectivity. One of the most significant aspects of the present method is that unactivated alkenes are suitable substrates for this method, which is distinctly different from nearly all other catalytic enantioselective [2 + 2] cycloaddition methods.
烯丙酸盐与烯烃之间的催化对映选择性[2+2]环加成反应被揭示。该方法适用于多种烯烃，并且产物具有优异的对映选择性。本方法的一个最重要的方面是，未活化的烯烃是该方法的合适底物，这与几乎所有其他催化对映选择性[2+2]环加成方法明显不同。
