Bakhit Amaar A, Kurdi Amr M, Wadera Junaid J, Alsuwaida Abdulkareem O
Department of Medicine, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2017 Jan;38(1):48-52. doi: 10.15537/smj.2017.1.17566.
To examin the effect of Ramadan fasting on worsening of renal function (WRF). Method: This was a single-arm prospective observational study including 65 patients with stage 3 or higher chronic kidney disease (CKD). By definition, WRF was considered to have occurred when serum creatinine levels increased by 0.3 mg/dL (26.5 µmol/l) from baseline during or within 3 months after Ramadan. The study was conducted in the Nephrology Clinic of King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia during the month of Ramadan 1436 AH (Hijiri), which corresponded to June 18-July 17, 2015. Results: This study included 65 adults with a mean age of 53 years. Overall, 33% of patients developed WRF. In the multivariate analysis, more advanced CKD stage, higher baseline systolic blood pressure and younger age were independently associated with WRF. Underlying cause of CKD, use of diuretics, use of renin angiotensin blockers, gender, and smoking status were not associated with WRF. Conclusion: In patients with stage 3 or higher CKD, Ramadan fasting during the summer months was associated with worsening of renal function. Clinicians need to warn CKD patients against Ramadan fasting.
为研究斋月禁食对肾功能恶化（WRF）的影响。方法：这是一项单臂前瞻性观察性研究，纳入了65例3期或更高分期的慢性肾脏病（CKD）患者。根据定义，当斋月期间或斋月后3个月内血清肌酐水平较基线水平升高0.3 mg/dL（26.5 µmol/l）时，即认为发生了肾功能恶化。该研究于回历1436年斋月期间（对应于2015年6月18日至7月17日）在沙特阿拉伯王国利雅得市哈立德国王大学医院肾病科进行。结果：本研究纳入了65名成年人，平均年龄为53岁。总体而言，33%的患者出现了肾功能恶化。在多变量分析中，更高的CKD分期、更高的基线收缩压和更年轻的年龄与肾功能恶化独立相关。CKD的潜在病因、利尿剂的使用、肾素血管紧张素阻滞剂的使用、性别和吸烟状况与肾功能恶化无关。结论：在3期或更高分期的CKD患者中，夏季斋月禁食与肾功能恶化有关。临床医生需要告诫CKD患者不要在斋月禁食。
