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慢性阻塞性肺疾病患者肺康复后的维持计划效果:一项随机对照试验。

The effects of maintenance schedules following pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomised controlled trial.

作者信息

Wilson Andrew M, Browne Paula, Olive Sandra, Clark Allan, Galey Penny, Dix Emma, Woodhouse Helene, Robinson Sue, Wilson Edward C F, Staunton Lindi

机构信息

Norwich Medical School, University of East Anglia, Norwich, UK Department of Respiratory Medicine, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.

Department of Respiratory Medicine, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK.

出版信息

BMJ Open. 2015 Mar 11;5(3):e005921. doi: 10.1136/bmjopen-2014-005921.

Abstract

OBJECTIVES

Pulmonary rehabilitation (PR) provides benefit for patients with chronic obstructive pulmonary disease (COPD) in terms of quality of life (QoL) and exercise capacity; however, the effects diminish over time. Our aim was to evaluate a maintenance programme for patients who had completed PR.

SETTING

Primary and secondary care PR programmes in Norfolk.

PARTICIPANTS

148 patients with COPD who had completed at least 60% of a standard PR programme were randomised and data are available for 110 patients. Patients had greater than 20 pack year smoking history and less than 80% predicted forced expiratory volume in 1 s but no other significant disease or recent respiratory tract infection.

INTERVENTIONS

Patients were randomised to receive a maintenance programme or standard care. The maintenance programme consisted of 2 h (1 h individually tailored exercise training and 1 h education programme) every 3 months for 1 year.

PRIMARY AND SECONDARY OUTCOME MEASURES

The Chronic Respiratory Questionnaire (CRQ) (primary outcome), endurance shuttle walk test (ESWT), EuroQol (EQ5D), hospital anxiety and depression score (HADS), body mass index (BMI), body fat, activity levels (overall score and activity diary) and exacerbations were assessed before and after 12 months.

RESULTS

There was no statistically significant difference between the groups for the change in CRQ dyspnoea score (primary end point) at 12 months which amounted to 0.19 (-0.26 to 0.64) units or other domains of the CRQ. There was no difference in the ESWT duration (-10.06 (-191.16 to 171.03) seconds), BMI, body fat, EQ5D, MET-minutes, activity rating, HADS, exacerbations or admissions.

CONCLUSIONS

A maintenance programme of three monthly 2 h sessions does not improve outcomes in patients with COPD after 12 months. We do not recommend that our maintenance programme is adopted. Other methods of sustaining the benefits of PR are required.

TRIAL REGISTRATION NUMBER

NCT00925171.

摘要

目的

肺康复(PR)在生活质量(QoL)和运动能力方面为慢性阻塞性肺疾病(COPD)患者带来益处;然而,随着时间推移效果会减弱。我们的目的是评估针对已完成PR的患者的维持计划。

设置

诺福克的初级和二级护理PR计划。

参与者

148例完成至少60%标准PR计划的COPD患者被随机分组,110例患者有可用数据。患者有超过20包年的吸烟史且第1秒用力呼气量低于预测值的80%,但无其他重大疾病或近期呼吸道感染。

干预措施

患者被随机分组接受维持计划或标准护理。维持计划包括每3个月进行2小时(1小时个体化定制运动训练和1小时教育计划),共1年。

主要和次要结局指标

在12个月前后评估慢性呼吸问卷(CRQ)(主要结局)、耐力穿梭步行试验(ESWT)、欧洲五维健康量表(EQ5D)、医院焦虑抑郁量表(HADS)、体重指数(BMI)、体脂、活动水平(总体评分和活动日记)以及急性加重情况。

结果

12个月时,两组间CRQ呼吸困难评分(主要终点)的变化无统计学显著差异,为0.19(-0.26至0.64)单位,CRQ的其他领域也无差异。ESWT持续时间(-10.06(-191.16至171.03)秒)、BMI、体脂、EQ5D、代谢当量分钟、活动评分、HADS、急性加重或住院情况均无差异。

结论

每3个月进行2小时疗程的维持计划在12个月后未改善COPD患者的结局。我们不建议采用我们的维持计划。需要其他维持PR益处的方法。

试验注册号

NCT00925171。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dae/4360719/5e8372b13883/bmjopen2014005921f01.jpg

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