Nakao K, Ohba N, Matsumoto M
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
Jpn J Ophthalmol. 1989;33(4):472-81.
A consecutive series of 34 patients with HTLV-I-associated myelopathy (HAM), a neurological disease associated with human T-lymphotropic virus type I (HTLV-I), were studied with reference to endogenous ocular disorders. These patients were examined at the Kagoshima University Hospital between 1986 and 1988. Five of the 34 HAM patients showed noninfectious, granulomatous anterior uveitis responding to corticosteroid therapy and/or retinal microvascular changes such as isolated cotton-wool spots; one of the patients had recurrent uveitis. Additionally, twelve of 30 patients who had been infected with HTLV-I but remained healthy systemically had ocular manifestations similar to those in HAM patients were included in this study. The ocular lesions in these patients were not explained by any established disorders that manifest uveitis or retinal microangiopathy. Some of the HTLV-I-seropositive patients with ocular disorders showed antibodies against HTLV-I in the aqueous humor. This might have resulted from diffusion of serum antibodies through a damaged blood-aqueous barrier or local synthesis of antibodies. The HTLV-I infection might be primarily responsible for a certain form of endogenous anterior uveitis that has remained hitherto etiologically undefined.
对34例与人类嗜T淋巴细胞病毒I型（HTLV-I）相关的脊髓病（HAM）患者进行了连续性研究，HAM是一种与HTLV-I相关的神经疾病，研究内容涉及内源性眼部疾病。这些患者于1986年至1988年期间在鹿儿岛大学医院接受检查。34例HAM患者中有5例表现为对皮质类固醇治疗有反应的非感染性肉芽肿性前葡萄膜炎和/或视网膜微血管改变，如孤立的棉絮斑；其中1例患者有复发性葡萄膜炎。此外，本研究纳入了30例感染了HTLV-I但全身健康的患者，他们有与HAM患者相似的眼部表现。这些患者的眼部病变无法用任何已确定的可表现为葡萄膜炎或视网膜微血管病变的疾病来解释。一些患有眼部疾病的HTLV-I血清阳性患者房水中显示出抗HTLV-I抗体。这可能是血清抗体通过受损的血-房水屏障扩散或抗体局部合成所致。HTLV-I感染可能是迄今病因不明的某种形式的内源性前葡萄膜炎的主要原因。
