Suppr超能文献

破伤风监测——美国,1991 - 1994年

Tetanus surveillance--United States, 1991-1994.

作者信息

Izurieta H S, Sutter R W, Strebel P M, Bardenheier B, Prevots D R, Wharton M, Hadler S C

机构信息

Epidemiology and Surveillance Division, National Immunization Program, USA.

出版信息

MMWR CDC Surveill Summ. 1997 Feb 21;46(2):15-25.

Abstract

PROBLEM/CONDITION: Despite the widespread availability of a safe and effective vaccine against tetanus, 201 cases of the disease were reported during 1991-1994. Of patients with known illness outcome, the case-fatality rate was 25%.

REPORTING PERIOD COVERED

1991-1994.

DESCRIPTION OF SYSTEM

Physician-diagnosed cases of tetanus are reported to local and state health departments, the latter of which reports these cases on a weekly basis to CDC's National Notifiable Disease Surveillance System. Since 1965, state health departments also have submitted supplemental clinical and epidemiologic information to CDC's National Immunization Program.

RESULTS

During 1991-1994, 201 cases of tetanus were reported from 40 states, for an average annual incidence of 0.02 cases per 100,000 population. Of the 188 patients for whom age was known, 101 (54%) were aged > or = 60 years and 10 (5%) were aged < 20 years. No cases of neonatal tetanus were reported. Among adults, the risk for tetanus increased with age; the risk for persons aged > or = 80 years was more than 10 times greater than the risk for persons aged 20-29 years. All deaths occurred among persons aged > or = 30 years. The case-fatality rate (overall: 25%) increased with age, from 11% in persons aged 30-49 years to 54% in persons aged > or = 80 years. Only 12% of all patients were reported to have received a primary series of tetanus toxoid before onset of illness. For 77% of patients, tetanus occurred after an acute injury was sustained. Of patients who obtained medical care for their injury, only 43% received tetanus toxoid as part of wound prophylaxis.

INTERPRETATION

The epidemiology of reported tetanus in the United States during 1991-1994 was similar to that during the 1980s. Tetanus continued to be a severe disease primarily of older adults who were unvaccinated or inadequately vaccinated. Most tetanus cases occurred after an acute injury was sustained, emphasizing the need for appropriate wound management.

ACTIONS TAKEN

In addition to decennial booster doses of tetanus-diphtheria toxoid during adult life, the Advisory Committee on Immunization Practices (ACIP) recommends vaccination visits for adolescents at age 11-12 years and for adults at age 50 years to enable health-care providers to review vaccination histories and administer any needed vaccine. Full implementation of the ACIP recommendations should virtually eliminate the remaining tetanus burden in the United States.

摘要

问题/状况:尽管有安全有效的破伤风疫苗广泛可得,但在1991年至1994年期间报告了201例该疾病。在已知疾病转归的患者中,病死率为25%。

报告期涵盖

1991年至1994年。

系统描述

医生诊断的破伤风病例报告给地方和州卫生部门,州卫生部门每周将这些病例报告给疾病控制与预防中心(CDC)的国家法定传染病监测系统。自1965年以来,州卫生部门还向CDC的国家免疫规划提交补充临床和流行病学信息。

结果

在1991年至1994年期间,40个州报告了201例破伤风病例,平均年发病率为每10万人0.02例。在已知年龄的188名患者中,101名(54%)年龄≥60岁,10名(5%)年龄<20岁。未报告新生儿破伤风病例。在成年人中,破伤风风险随年龄增加;80岁及以上人群的风险比20 - 29岁人群的风险高10倍以上。所有死亡均发生在30岁及以上人群中。病死率(总体:25%)随年龄增加,从30 - 49岁人群中的11%增至80岁及以上人群中的54%。据报告,所有患者中只有12%在发病前接受过破伤风类毒素的全程基础免疫接种。77%的患者在遭受急性损伤后发生破伤风。在因损伤接受医疗护理的患者中,只有43%接受了破伤风类毒素作为伤口预防措施的一部分。

解读

1991年至1994年美国报告的破伤风流行病学情况与20世纪80年代相似。破伤风仍然是一种主要影响未接种疫苗或接种不足的老年人的严重疾病。大多数破伤风病例发生在遭受急性损伤后,这强调了适当伤口处理的必要性。

采取的行动

除了在成年期每十年接种一次破伤风 - 白喉类毒素加强剂外,免疫实践咨询委员会(ACIP)建议对11 - 12岁的青少年和50岁的成年人进行疫苗接种问诊,以便医疗保健提供者审查疫苗接种史并接种任何所需疫苗。全面实施ACIP的建议应能基本消除美国剩余的破伤风负担。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验