Li Honglong, Pan Haobo, Ning Chengyun, Tan Guoxin, Liao Jingwen, Ni Guoxin
School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
J Mater Sci Mater Med. 2015 Mar;26(3):147. doi: 10.1007/s10856-015-5428-0. Epub 2015 Mar 13.
Numerous modification methods have been reported to enhance the corrosion resistance of magnesium with positive results. However, little attention has been paid on their impact on micro-environment, particularly the ion concentration and local pH value. In this study, two different coatings were prepared on magnesium, one with porous micro-arc oxidation (MAO) coating alone, and the other with additional polymer polyhydroxybutyrate (PHB) membrane using spinning technique. Their in vitro corrosional and biological behaviors were investigated and compared. Both coatings were found to reduce the degradation rate of magnesium, but an additionally deposited PHB membrane was superior to MAO-coated magnesium since it could produce a micro-environment with preferable local pH value and ion concentration for osteoblast proliferation. Our study suggests that micro-environment should be another critical issue in evaluation of a modification method for orthopaedic implants.
据报道，有许多改性方法可提高镁的耐腐蚀性，且效果良好。然而，它们对微环境的影响，特别是离子浓度和局部pH值，却很少受到关注。在本研究中，在镁上制备了两种不同的涂层，一种仅采用多孔微弧氧化（MAO）涂层，另一种采用纺丝技术额外添加聚合物聚羟基丁酸酯（PHB）膜。对它们的体外腐蚀和生物学行为进行了研究和比较。发现两种涂层均能降低镁的降解速率，但额外沉积的PHB膜优于MAO涂层的镁，因为它可以产生一个对成骨细胞增殖具有更适宜局部pH值和离子浓度的微环境。我们的研究表明，微环境应是评估骨科植入物改性方法时的另一个关键问题。
