Choi Janggyoo, Cho Jae Youl, Choi Soo Jung, Jeon Heejin, Kim Young Dong, Htwe Khin Myo, Chin Young Won, Lee Woo Shin, Kim Jinwoong, Yoon Kee Dong
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea.
Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea.
Molecules. 2015 Mar 10;20(3):4483-91. doi: 10.3390/molecules20034483.
Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM.
从紫薇的地上部分分离出两种新的酚苷，即1-O-苄基-6-O-E-咖啡酰基-β-D-吡喃葡萄糖苷和1-O-(7S,8R)-愈创木醇甘油-(6-O-E-咖啡酰基)-β-D-吡喃葡萄糖苷，以及十种已知化合物。根据一维和二维核磁共振、Q-TOF质谱和旋光光谱数据确定了分离出的化合物的结构。所有化合物在脂多糖处理的RAW264.7细胞中均表现出对一氧化氮产生的中等抑制活性，IC50值为69.5 - 83.3 μM。
