Ghoshegir S Ashraffodin, Mazaheri Mohammad, Ghannadi Alireza, Feizi Awat, Babaeian Mahmoud, Tanhaee Maryam, Karimi Mehrdad, Adibi Peyman
Department of Iranian Traditional Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Iranian Traditional Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2015 Jan;20(1):13-21.
We aimed to evaluate the effects of Pimpinella anisum (anise) from Apiaceae family on relieving the symptoms of postprandial distress syndrome (PDS) in this double-blind randomized clinical trial.
Totally, 107 patients attending the gastroenterology clinic, aged 18-65 years, diagnosed with PDS according to ROME III criteria and signed a written consent form were enrolled. They were randomized to receive either anise or placebo, blindly, for 4 weeks. Anise group included 47 patients and received anise powders, 3 g after each meal (3 times/day). Control group involved 60 patients and received placebo powders (corn starch), 3 gafter each meal (3 times/day). The severity of Functional dyspepsia (FD) symptoms was assessed by FD severity scale. Assessments were done at baseline and by the end of weeks 2, 4 and 12. Mean scores of severity of FD symptoms and the frequency distribution of patients across the study period were compared.
The age, sex, body mass index, smoking history, and coffee drinking pattern of the intervention and control groups were not significantly different. Mean (standard deviation) total scores of FD severity scale before intervention in the anise and control groups were 10.6 (4.1) and 10.96 (4.1), respectively (P = 0.6). They were 7.04 (4.1) and 12.30 (4.3) by week 2, respectively (P = 0.0001), 2.44 (4.2) and 13.05 (5.2) by week 4, respectively (P = 0.0001), and 1.08 (3.8) and 13.30 (6.2) by week 12, respectively (P = 0.0001).
This study showed the effectiveness of anise in relieving the symptoms of postpartum depression. The findings were consistent across the study period at weeks 2, 4 and 12.
在这项双盲随机临床试验中，我们旨在评估伞形科植物茴芹对缓解餐后不适综合征（PDS）症状的效果。
总共招募了107名年龄在18至65岁之间、在胃肠病诊所就诊、根据罗马III标准被诊断为PDS并签署书面知情同意书的患者。他们被随机分为两组，分别接受茴芹或安慰剂治疗，为期4周，治疗过程为盲法。茴芹组包括47名患者，每餐饭后服用3克茴芹粉（每日3次）。对照组有60名患者，每餐饭后服用3克安慰剂粉（玉米淀粉，每日3次）。通过功能性消化不良（FD）严重程度量表评估FD症状的严重程度。在基线时以及第2、4和12周结束时进行评估。比较了FD症状严重程度的平均得分以及整个研究期间患者的频率分布。
干预组和对照组的年龄、性别、体重指数、吸烟史和咖啡饮用模式没有显著差异。茴芹组和对照组干预前FD严重程度量表的平均（标准差）总分分别为10.6（4.1）和10.96（4.1）（P = 0.6）。到第2周时，分别为7.04（4.1）和12.30（4.3）（P = 0.0001）；到第4周时，分别为2.44（4.2）和13.05（5.2）（P = 0.0001）；到第12周时，分别为1.08（3.8）和13.30（6.2）（P = 0.0001）。
本研究表明茴芹对缓解产后抑郁症状有效。在第2、4和12周的整个研究期间，研究结果一致。
