Shojaii Asie, Abdollahi Fard Mehri
Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Lalezar Street, Jomhuri Avenue, P.O. Box 1145847111, Tehran, Iran.
ISRN Pharm. 2012;2012:510795. doi: 10.5402/2012/510795. Epub 2012 Jul 16.
Pimpinella anisum (anise), belonging to Umbelliferae family, is an aromatic plant which has been used In Iranian traditional medicine (especially its fruits) as carminative, aromatic, disinfectant, and galactagogue. Because the wide traditional usage of Pimpinella anisum for treatment of diseases, in this review published scientific reports about the composition and pharmacological properties of this plant were collected with electronic literature search of GoogleScholar, PubMed, Sciencedirect, Scopus, and SID from 1970 to 2011. So far, different studies were performed on aniseeds and various properties such as antimicrobial, antifungal, antiviral, antioxidant, muscle relaxant, analgesic and anticonvulsant activity as well as different effects on gastrointestinal system have been reported of aniseeds. It can also reduce morphine dependence and has beneficial effects on dysmenorrhea and menopausal hot flashes in women. In diabetic patients, aniseeds showed hypoglycemic and hypolipidemic effect and reduce lipid peroxidation. The most important compounds of aniseeds essential oil were trans-anetole, estragole, γ-hymachalen, para-anisaldehyde and methyl cavicol. Due to broad spectrum of pharmacological effects, and very few clinical studies of Pimpinella anisum, more clinical trials are recommended to evaluate the beneficial effects of this plant in human models and synthesis of new drugs from the active ingredients of this plant in future.
茴芹，属于伞形科，是一种芳香植物，其果实已被用于伊朗传统医学，用作驱风剂、芳香剂、消毒剂和催乳剂。由于茴芹在治疗疾病方面有广泛的传统用途，在本综述中，通过对谷歌学术、PubMed、科学Direct、Scopus和SID进行1970年至2011年的电子文献检索，收集了有关该植物成分和药理特性的科学报告。到目前为止，已经对茴芹籽进行了不同的研究，报道了茴芹籽的各种特性，如抗菌、抗真菌、抗病毒、抗氧化、肌肉松弛、镇痛和抗惊厥活性以及对胃肠道系统的不同影响。它还可以降低吗啡依赖性，并对女性痛经和更年期潮热有有益作用。在糖尿病患者中，茴芹籽显示出降血糖和降血脂作用，并减少脂质过氧化。茴芹籽精油中最重要的化合物是反式茴香脑、草蒿脑、γ-衣兰烯、对甲氧基苯甲醛和甲基香芹酚。由于茴芹具有广泛的药理作用，而关于茴芹的临床研究很少，建议未来进行更多的临床试验，以评估这种植物在人体模型中的有益作用，并从该植物的活性成分中合成新药。
