Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran.
Biomed Res Int. 2013;2013:692751. doi: 10.1155/2013/692751. Epub 2013 Jul 7.
Epilepsy is a brain disorder which affects about 50 million people worldwide. Ineffectiveness of the drugs in some cases and the serious side effects and chronic toxicity of the antiepileptic drugs lead to use of herbal medicine as a form of complementary and alternative medicine. In this review modern evidences for the efficacy of antiepileptic medicinal plants in Traditional Iranian Medicine (TIM) will be discussed. For this purpose electronic databases including PubMed, Scopus, Sciencedirect, and Google Scholar were searched for each of the antiepileptic plants during 1970-February 2013.Anticonvulsant effect of some of the medicinal plants mentioned in TIM like Anacyclus pyrethrum, Pimpinella anisum, Nigella sativa, and Ferula gummosa was studied with different models of seizure. Also for some of these plants like Nigella sativa or Piper longum the active constituent responsible for antiepileptic effect was isolated and studied. For some of the herbal medicine used in TIM such as Pistacia lentiscus gum (Mastaki), Bryonia alba (Fashra), Ferula persica (Sakbinaj), Ecballium elaterium (Ghesa-al Hemar), and Alpinia officinarum (Kholanjan) there is no or not enough studies to confirm their effectiveness in epilepsy. It is suggested that an evaluation of the effects of these plants on different epileptic models should be performed.
癫痫是一种影响全球约 5000 万人的脑部疾病。某些情况下药物的无效性，以及抗癫痫药物的严重副作用和慢性毒性，导致人们使用草药作为补充和替代医学的一种形式。在本次综述中，将讨论传统伊朗医学（TIM）中具有抗癫痫作用的药用植物的现代证据。为此，在 1970 年至 2013 年 2 月期间，我们针对 TIM 中提到的每种抗癫痫植物，在包括 PubMed、Scopus、Sciencedirect 和 Google Scholar 在内的电子数据库中进行了搜索。一些 TIM 中提到的药用植物，如 Anacyclus pyrethrum、Pimpinella anisum、Nigella sativa 和 Ferula gummosa，具有抗惊厥作用，其作用已经在不同的癫痫模型中得到了研究。此外，对于某些植物，如 Nigella sativa 或 Piper longum，负责抗癫痫作用的活性成分已被分离并进行了研究。对于 TIM 中使用的一些草药，如 Pistacia lentiscus gum（Mastaki）、Bryonia alba（Fashra）、Ferula persica（Sakbinaj）、Ecballium elaterium（Ghesa-al Hemar）和 Alpinia officinarum（Kholanjan），目前还没有足够的研究来证实它们在癫痫中的有效性。因此，建议应对这些植物对不同癫痫模型的作用进行评估。
