Chiang C H, Hwang J C, Liu J C
Taiwan Yi Xue Hui Za Zhi. 1989 Oct;88(10):973-7.
Only limited information relating neurotransmitters to central regulation of the respiratory system exists. L-glutamic acid has been proposed as the primary neurotransmitter in the nucleus of the tractus solitarius (NTS) of cats. To test whether or not glutamic acid has an effect on the respiratory center, we microinjected L-glutamic acid (1 M, 0.1 microliter) via a 1 microliter Hamilton microsyringe into the ventrolateral area of the NTS dorsal respiratory groups (DRG) of unanesthetized, decerebrated cats at two-second intervals with continuous monitoring of tidal volume (VT), respiratory rate (f), end tidal CO2, blood pressure and heart rate. The results showed that glutamate induced the following respiratory changes: VT and f increased; VT and f decreased; and VT decreased but f increased. In addition to VT or f changes elicited by glutamate microinjection, changes in other rhythmic patterns such as apnea, apneusis and irregular respiration were observed. Glutamic acid appears to play a significant role in the modulation of the respiratory drive in the DRG. We, therefore, suggest that the excitatory amino acid L-glutamic acid may be involved in central respiratory control.
关于神经递质与呼吸系统中枢调节之间的相关信息非常有限。L-谷氨酸已被认为是猫孤束核（NTS）中的主要神经递质。为了测试谷氨酸是否对呼吸中枢有影响，我们通过1微升的汉密尔顿微量注射器，以两秒的间隔，将L-谷氨酸（1 M，0.1微升）微量注射到未麻醉、去大脑猫的NTS背侧呼吸组（DRG）的腹外侧区域，同时持续监测潮气量（VT）、呼吸频率（f）、呼气末二氧化碳、血压和心率。结果显示，谷氨酸引起了以下呼吸变化：VT和f增加；VT和f降低；VT降低但f增加。除了谷氨酸微量注射引起的VT或f变化外，还观察到其他节律模式的变化，如呼吸暂停、长吸式呼吸和不规则呼吸。谷氨酸似乎在DRG呼吸驱动的调节中发挥着重要作用。因此，我们认为兴奋性氨基酸L-谷氨酸可能参与中枢呼吸控制。
