Cardiorespiratory effects produced by application of L-glutamic and kainic acid to the ventral surface of the cat hindbrain.

The purpose of our study was to determine the cardiorespiratory effects of exciting cell bodies at the rostral (area M), intermediate (area S), and caudal (area L) chemosensitive sites on the ventral surface of the medulla. To do this, L-glutamic and kainic acid were applied bilaterally to each chemosensitive site while monitoring tidal volume (VT), respiratory rate (f), mean arterial pressure (BP), and heart rate (HR) in chloralose-anesthetized cats. Application of solutions (5 microliter) of L-glutamic acid ranging from 62.5 to 2000 mM to the intermediate area produced concentration-dependent increases in VT (from 2.0 +/- 0.6 ml to 14 +/- 1.1 ml) and BP (from 2.0 +/- 1.7 mm Hg to 39 +/- 5.3 mm Hg). No significant changes in f and HR were noted. Similar effects were observed with application of kainic acid. Application of L-glutamic acid to the caudal area produced hypotension (-24 +/- 5.4 mm Hg) with no accompanying changes in VT and f. No responses were observed after application of L-glutamic acid to the rostral area. These data suggest that activation of cell bodies on the intermediate area produces simultaneous stimulatory effects on BP and VT, whereas activation of cell bodies at the caudal area produces selective depressant effects on BP.