Gatti P J, Taveira da Silva A M, Hamosh P, Gillis R A
Brain Res. 1985 Mar 18;330(1):21-9. doi: 10.1016/0006-8993(85)90004-6.
The purpose of our study was to determine the cardiorespiratory effects of exciting cell bodies at the rostral (area M), intermediate (area S), and caudal (area L) chemosensitive sites on the ventral surface of the medulla. To do this, L-glutamic and kainic acid were applied bilaterally to each chemosensitive site while monitoring tidal volume (VT), respiratory rate (f), mean arterial pressure (BP), and heart rate (HR) in chloralose-anesthetized cats. Application of solutions (5 microliter) of L-glutamic acid ranging from 62.5 to 2000 mM to the intermediate area produced concentration-dependent increases in VT (from 2.0 +/- 0.6 ml to 14 +/- 1.1 ml) and BP (from 2.0 +/- 1.7 mm Hg to 39 +/- 5.3 mm Hg). No significant changes in f and HR were noted. Similar effects were observed with application of kainic acid. Application of L-glutamic acid to the caudal area produced hypotension (-24 +/- 5.4 mm Hg) with no accompanying changes in VT and f. No responses were observed after application of L-glutamic acid to the rostral area. These data suggest that activation of cell bodies on the intermediate area produces simultaneous stimulatory effects on BP and VT, whereas activation of cell bodies at the caudal area produces selective depressant effects on BP.
我们研究的目的是确定刺激延髓腹侧面头端（M区）、中间（S区）和尾端（L区）化学敏感部位的细胞体对心肺功能的影响。为此，在监测水合氯醛麻醉猫的潮气量（VT）、呼吸频率（f）、平均动脉压（BP）和心率（HR）时，将L-谷氨酸和海人酸双侧应用于每个化学敏感部位。将浓度范围为62.5至2000 mM的L-谷氨酸溶液（5微升）应用于中间区域，可使VT（从2.0±0.6毫升增加到14±1.1毫升）和BP（从2.0±1.7毫米汞柱增加到39±5.3毫米汞柱）呈浓度依赖性增加。未观察到f和HR有显著变化。应用海人酸时也观察到类似效果。将L-谷氨酸应用于尾端区域可导致低血压（-24±5.4毫米汞柱），而VT和f无相应变化。将L-谷氨酸应用于头端区域后未观察到反应。这些数据表明，中间区域细胞体的激活对BP和VT产生同时的刺激作用，而尾端区域细胞体的激活对BP产生选择性抑制作用。
