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核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

超极化15N-吡啶衍生物作为pH敏感的磁共振成像剂。

Hyperpolarized 15N-pyridine derivatives as pH-sensitive MRI agents.

作者信息

Jiang Weina, Lumata Lloyd, Chen Wei, Zhang Shanrong, Kovacs Zoltan, Sherry A Dean, Khemtong Chalermchai

机构信息

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

1] Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA [2] Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75083, USA.

出版信息

Sci Rep. 2015 Mar 16;5:9104. doi: 10.1038/srep09104.

DOI:10.1038/srep09104
PMID:25774436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4360734/
Abstract

Highly sensitive MR imaging agents that can accurately and rapidly monitor changes in pH would have diagnostic and prognostic value for many diseases. Here, we report an investigation of hyperpolarized (15)N-pyridine derivatives as ultrasensitive pH-sensitive imaging probes. These molecules are easily polarized to high levels using standard dynamic nuclear polarization (DNP) techniques and their (15)N chemical shifts were found to be highly sensitive to pH. These probes displayed sharp (15)N resonances and large differences in chemical shifts (Δδ > 90 ppm) between their free base and protonated forms. These favorable features make these agents highly suitable candidates for the detection of small changes in tissue pH near physiological values.

摘要

能够准确、快速监测pH值变化的高灵敏度磁共振成像剂对许多疾病具有诊断和预后价值。在此，我们报告了对超极化（15）N-吡啶衍生物作为超灵敏pH敏感成像探针的研究。这些分子使用标准动态核极化（DNP）技术很容易极化到高水平，并且发现它们的（15）N化学位移对pH值高度敏感。这些探针显示出尖锐的（15）N共振，并且其游离碱形式和质子化形式之间的化学位移差异很大（Δδ>90 ppm）。这些有利特性使这些试剂成为检测生理值附近组织pH微小变化的非常合适的候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/19d6acf71f98/srep09104-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/9bada485c385/srep09104-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/ae012ff002bf/srep09104-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/c7829537c90a/srep09104-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/87e16ded86e5/srep09104-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/19d6acf71f98/srep09104-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/9bada485c385/srep09104-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/ae012ff002bf/srep09104-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/c7829537c90a/srep09104-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/87e16ded86e5/srep09104-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1f2/4360734/19d6acf71f98/srep09104-f5.jpg

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引用本文的文献

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Nanoscale. 2024-10-24

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[3]
Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance.

Natl Sci Rev. 2024-6-29

[4]
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[5]
Nature of GaO Shells Grown on Silica by Atomic Layer Deposition.

Chem Mater. 2023-8-28

[6]
Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions.

Sci Adv. 2023-8-25

[7]
Nitrogen atom insertion into indenes to access isoquinolines.

Chem Sci. 2023-2-23

[8]
Tuning the pH of Activation of Fluorinated Hydrazone-Based Switches─A Pathway to Versatile F Magnetic Resonance Imaging Contrast Agents.

ACS Sens. 2023-2-24

[9]
Design, synthesis and evaluation of N- and C-labeled molecular probes as hyperpolarized nitric oxide sensors.

Bioorg Med Chem. 2022-10-15

[10]
State-of-the-art accounts of hyperpolarized N-labeled molecular imaging probes for magnetic resonance spectroscopy and imaging.

Chem Sci. 2022-5-17

本文引用的文献

[1]
Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.

Biochemistry. 2014-12-2

[2]
A platform for designing hyperpolarized magnetic resonance chemical probes.

Nat Commun. 2013

[3]
Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis.

Cancer Res. 2013-6-10

[4]
Probing early tumor response to radiation therapy using hyperpolarized [1-¹³C]pyruvate in MDA-MB-231 xenografts.

PLoS One. 2013-2-12

[5]
The physiological action of picolinic Acid in the human brain.

Int J Tryptophan Res. 2009

[6]
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging.

Proc Natl Acad Sci U S A. 2011-10-31

[7]
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.

Chemistry. 2011-9-19

[8]
Exchange facilitated indirect detection of hyperpolarized 15ND2-amido-glutamine.

J Magn Reson. 2011-7-21

[9]
Imaging pH with hyperpolarized 13C.

NMR Biomed. 2011-8-3

[10]
DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.

J Am Chem Soc. 2011-5-13

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