分泌型白细胞蛋白酶抑制剂对吞噬作用过程中释放的白细胞蛋白酶的影响。
The effect of the secretory leukocyte protease inhibitor on leukocyte proteases released during phagocytosis.
作者信息
Axelsson L, Linder C, Ohlsson K, Rosengren M
机构信息
Department of Surgical Pathophysiology, University of Lund, Malmö General Hospital, Sweden.
出版信息
Biol Chem Hoppe Seyler. 1988 May;369 Suppl:89-93.
PMID:2578013
Abstract
The human secretory leukocyte protease inhibitor effectively binds and blocks the digestive activity of elastase released from PMN leukocytes during phagocytosis of opsonized yeast particles. About 25% of the alpha 1-protease inhibitor present in the incubation medium is inactivated during the phagocytosis, while the secretory leukocyte protease inhibitor retains more than 90% of its inhibiting capacity.
摘要
人分泌型白细胞蛋白酶抑制剂能有效结合并阻断在调理酵母颗粒吞噬过程中PMN白细胞释放的弹性蛋白酶的消化活性。在吞噬过程中，孵育培养基中约25%的α1-蛋白酶抑制剂失活，而分泌型白细胞蛋白酶抑制剂保留了超过90%的抑制能力。
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