三氟甲磺酸2-环丙基-1-（三氟甲基）苯并[b]噻吩鎓催化芳基硼酸和乙烯基硼酸的三氟甲基化反应
Catalytic trifluoromethylation of aryl- and vinylboronic acids by 2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate.
作者信息
Arimori Sadayuki, Shibata Norio
机构信息
Department of Frontier Materials, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
出版信息
Org Lett. 2015 Apr 3;17(7):1632-5. doi: 10.1021/acs.orglett.5b00164. Epub 2015 Mar 18.
PMID:25783441
Abstract
Catalytic trifluoromethylation of aryl- and vinylboronic acids by 2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate is described. In the presence of a catalytic amount of CuOAc and 2,4,6-collidine in ethyl acetate, the reaction proceeded in good to high yields for various substrates under mild reaction conditions at room temperature.
摘要
描述了用三氟甲磺酸2-环丙基-1-(三氟甲基)苯并[b]噻吩鎓对芳基硼酸和乙烯基硼酸进行催化三氟甲基化反应。在乙酸乙酯中，在催化量的醋酸铜和2,4,6-可力丁存在下，该反应在室温温和反应条件下对各种底物都能以良好到高产率进行。
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