School of Public Health, Boston University, Boston, MA, USA.
Axe santé des populations et pratiques optimales en santé, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Int J Circumpolar Health. 2024 Dec;83(1):2421048. doi: 10.1080/22423982.2024.2421048. Epub 2024 Oct 26.
The global use of pesticides is increasing; however, few studies have examined the exposure of current-use pesticide exposure in Inuit populations. Some current use pesticides are also capable of long-range transport, potentially increasing exposures to northern populations. The study aim was to analyse pesticide (chlorophenoxy, organophosphates, and pyrethroid pesticide) biomarker levels in pooled samples from an Inuit population in Nunavik, Quebec. Thirty pooled samples from the Qanuilirpitaa? 2017 survey (Q2017) from individuals aged 16-80 years were included. Creatinine-adjusted arithmetic (AM) were compared by sex, age, and region sub-groups, and geometric mean concentrations (GM) were compared to those in the Canadian Health Measures Survey (CHMS). Most analysed pesticide biomarkers were detected, and PNP (a metabolite of methyl and ethyl parathion), trans-DCCA (a metabolite of pyrethroids), and 3,5,6-TCP (a metabolite of chlorpyrifos) had the highest concentrations. Concentrations in Q2017 were largely similar to or less than CHMS concentrations. Although not significant, there was a general increase in 2,4-D (a chlorophenoxy biomarker), 3,5,6-TCP, 3-PBA (a metabolite of pyrethroids), and trans-DCCA with increasing age. Concentrations were also somewhat higher in females versus males, but these were not significant. Environmental exposures to current use pesticides were detected in Nunavik and concentrations were similar to or less than those in the general Canadian population. Regular monitoring of current use pesticide exposures is recommended given the increasing global use of pesticides.
全球范围内农药的使用量正在增加；然而，很少有研究检查过因纽特人群中当前使用农药的暴露情况。一些当前使用的农药也能够进行长距离运输，这可能会增加北方人群的暴露量。本研究的目的是分析魁北克努纳武特因纽特人 2017 年（Q2017）调查中采集的 pooled 样本中的农药（氯苯氧基、有机磷和拟除虫菊酯类农药）生物标志物水平。共纳入了 30 个来自 Q2017 中年龄在 16-80 岁的个体的 pooled 样本。按性别、年龄和地区亚组比较肌酐调整的算术平均值（AM），并将几何平均值（GM）与加拿大健康测量调查（CHMS）进行比较。大多数分析的农药生物标志物都被检测到，其中 PNP（甲基和乙基对硫磷的代谢物）、trans-DCCA（拟除虫菊酯的代谢物）和 3,5,6-TCP（氯吡硫磷的代谢物）的浓度最高。Q2017 的浓度与 CHMS 的浓度相似或更低。虽然没有统计学意义，但随着年龄的增加，2,4-D（氯苯氧基生物标志物）、3,5,6-TCP、3-PBA（拟除虫菊酯的代谢物）和 trans-DCCA 呈普遍升高趋势。女性的浓度也略高于男性，但无统计学意义。在努纳武特地区检测到了当前使用的农药的环境暴露，其浓度与加拿大一般人群相似或更低。鉴于全球范围内农药使用量的增加，建议定期监测当前使用农药的暴露情况。
