载脂蛋白基因多态性与股骨头坏死易感性的关系：一项荟萃分析。

The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis.

机构信息

Department of Osteonecrosis and Joint Reconstruction, Honghui Hospital Xi'an Jiao Tong University Health Science Center, No. 555 Youyi East Road, Shaanxi, 710054, Xi'an, People's Republic of China.

Shaanxi University of Chinese Medicine, Shiji Ave, Xi'an-Xianyang New Ecomic Zone, Shaanxi, 712046, Xi'an, People's Republic of China.

出版信息

Lipids Health Dis. 2018 Aug 17;17(1):192. doi: 10.1186/s12944-018-0827-0.

BACKGROUND

The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH).

METHODS

The relevant literature was screened from databases of Pubmed, Embase, Wanfang, Weipu and China National Knowledge Internet (CNKI) until May, 2017. In addition, odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as a measure of effect size for calculating effect size.

RESULTS

Totally, six case-control studies were included in this meta-analysis. It revealed that ApoB-C7623T polymorphism frequency was increased in ONFH group than in control group under three genetic models, including allele model (T vs. C, OR = 4.5149, 95% CI: 1.6968-12.0134); additive model (TC vs. CC, OR = 6.2515, 95% CI: 2.0939-18.6640); and dominant model (TT + TC vs. CC, OR = 5.4998, 95% CI: 1.9246-15.7163). In addition, the increased risk of ONFH were related to ApoA1-rs1799837 polymorphism under additive model (AA vs. GG, OR = 1.4175, 95% CI: 1.0522-1.9096) and recessive model (AA vs. GG + AG, OR = 1.7727, 95% CI: 1.3399-2.3452). However, four ApoB rs1042031, rs693, 3'-VNTR and G12619A polymorphisms under the all genetic models were not associated with susceptibility to ONFH.

CONCLUSION

The T allele and TC genotype of ApoB-C7623T and AA genotype of ApoA1-rs1799837 may contribute to increase the risk of ONFH.

背景

本研究旨在评估载脂蛋白基因多态性是否与股骨头坏死（ONFH）易感性相关。

方法

从 Pubmed、Embase、万方、维普和中国知网（CNKI）数据库中筛选出相关文献，检索时间截至 2017 年 5 月。另外，使用比值比（OR）及其 95%置信区间（CI）作为衡量效应大小的指标来计算效应大小。

结果

本荟萃分析共纳入了 6 项病例对照研究。结果显示，在 3 种遗传模型（等位基因模型：T 对 C，OR=4.5149，95%CI：1.6968-12.0134；加性模型：TC 对 CC，OR=6.2515，95%CI：2.0939-18.6640；显性模型：TT+TC 对 CC，OR=5.4998，95%CI：1.9246-15.7163）中，ApoB-C7623T 多态性在 ONFH 组的频率高于对照组。另外，在加性模型（AA 对 GG，OR=1.4175，95%CI：1.0522-1.9096）和隐性模型（AA 对 GG+AG，OR=1.7727，95%CI：1.3399-2.3452）中，ApoA1-rs1799837 多态性与 ONFH 的发病风险增加相关。然而，在所有遗传模型下，ApoB rs1042031、rs693、3'-VNTR 和 G12619A 多态性与 ONFH 易感性均无相关性。