Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea.
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea; Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea.
Acta Biomater. 2015 Jul;21:2-19. doi: 10.1016/j.actbio.2015.03.013. Epub 2015 Mar 16.
Scaffolds that secure and deliver therapeutic ingredients like signaling molecules and stem cells hold great promise for drug delivery and tissue engineering. Employing a core-shell design for scaffolds provides a promising solution. Some unique methods, such as co-concentric nozzle extrusion, microfluidics generation, and chemical confinement reactions, have been successful in producing core-shelled nano/microfibers and nano/microspheres. Signaling molecules and drugs, spatially allocated to the core and/or shell part, can be delivered in a controllable and sequential manner for optimal therapeutic effects. Stem cells can be loaded within the core part on-demand, safely protected from the environments, which ultimately affords ex vivo culture and in vivo tissue engineering. The encapsulated cells experience three-dimensional tissue-mimic microenvironments in which therapeutic molecules are secreted to the surrounding tissues through the semi-permeable shell. Tuning the material properties of the core and shell, changing the geometrical parameters, and shaping them into proper forms significantly influence the release behaviors of biomolecules and the fate of the cells. This topical issue highlights the immense usefulness of core-shell designs for the therapeutic actions of scaffolds in the delivery of signaling molecules and stem cells for tissue regeneration and disease treatment.
支架可以固定和输送治疗成分，如信号分子和干细胞，为药物输送和组织工程带来了巨大的前景。采用核壳设计的支架是一种很有前途的解决方案。一些独特的方法，如共同轴喷嘴挤出、微流体制备和化学限制反应，已经成功地制备了核壳纳米/微米纤维和纳米/微球。信号分子和药物可以空间分配到核心和/或壳部分，以可控和顺序的方式输送，以达到最佳的治疗效果。干细胞可以按需加载到核心部分，安全地免受环境影响，从而可以进行体外培养和体内组织工程。包封的细胞在三维组织模拟的微环境中经历，其中治疗分子通过半渗透壳分泌到周围组织中。调节核心和壳的材料特性、改变几何参数并将其塑造成适当的形状，显著影响生物分子的释放行为和细胞的命运。这个专题强调了核壳设计在支架治疗作用中的巨大用处，它可以输送信号分子和干细胞，用于组织再生和疾病治疗。
