Sperling Laura E, Reis Karina P, Pranke Patricia, Wendorff Joachim H
Hematology and Stem Cell Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Hematology and Stem Cell Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post Graduate Program in Physiology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Drug Discov Today. 2016 Aug;21(8):1243-56. doi: 10.1016/j.drudis.2016.04.024. Epub 2016 May 4.
Whereas highly porous scaffolds composed of electrospun nanofibers can mimick major features of the extracellular matrix in tissue engineering, they lack the ability to incorporate and release biocompounds (drugs, growth factors) safely in a controlled way. Here, electrospun core-shell fibers (core made from water and aqueous solutions of hydrophilic polymers and the shell from materials with well-defined release mechanisms) offer unique advantages in comparison with those that have helped make porous nanofibrillar scaffolds highly successful in tissue engineering. This review considers the preparation and biofunctionalization of such core-shell fibers as well as applications in various areas, including neural, vascular, cardiac, cartilage and bone tissue engineering, and touches on the topic of clinical trials.
虽然由电纺纳米纤维组成的高度多孔支架可以模拟组织工程中细胞外基质的主要特征，但它们缺乏以可控方式安全地掺入和释放生物化合物（药物、生长因子）的能力。在这里，与那些有助于使多孔纳米纤维支架在组织工程中取得巨大成功的支架相比，电纺核壳纤维（核由水和亲水性聚合物的水溶液制成，壳由具有明确释放机制的材料制成）具有独特的优势。本文综述了此类核壳纤维的制备、生物功能化以及在神经、血管、心脏、软骨和骨组织工程等各个领域的应用，并涉及了临床试验的主题。
