Gibbs A R, Harach R, Wagner J C, Jasani B
Thorax. 1985 Feb;40(2):91-5. doi: 10.1136/thx.40.2.91.
Immunohistological methods were used to investigate the presence of carcinoembryonic antigen, beta 1 pregnancy specific glycoprotein, beta subunit of human chorionic gonadotrophin, human placental lactogen, calcitonin, and keratin in formalin fixed tissue from 29 malignant mesotheliomas and 27 pulmonary adenocarcinomas. Malignant mesotheliomas were negative for tumour markers except for the beta subunit of human chorionic gonadotrophin and keratin, one and 13 cases respectively being positive for these. Pulmonary adenocarcinomas, however, were frequently positive for tumour markers--namely, carcinoembryonic antigen, beta 1 pregnancy specific glycoprotein, beta subunit of human chorionic gonadotrophin, human placental lactogen, calcitonin, and keratin. The presence of carcinoembryonic antigen and beta 1 pregnancy specific glycoprotein within an intrathoracic tumour is strong evidence against its being of mesothelial origin.
采用免疫组织学方法，对29例恶性间皮瘤和27例肺腺癌的福尔马林固定组织进行检测，以研究癌胚抗原、β1妊娠特异性糖蛋白、人绒毛膜促性腺激素β亚基、人胎盘催乳素、降钙素和角蛋白的存在情况。除人绒毛膜促性腺激素β亚基和角蛋白外，恶性间皮瘤的肿瘤标志物均为阴性，这两种标志物分别有1例和13例呈阳性。然而，肺腺癌的肿瘤标志物常常呈阳性，即癌胚抗原、β1妊娠特异性糖蛋白、人绒毛膜促性腺激素β亚基、人胎盘催乳素、降钙素和角蛋白。胸内肿瘤中存在癌胚抗原和β1妊娠特异性糖蛋白，强烈提示该肿瘤并非间皮来源。
