De Leon John Mark S, Cheung Carol Y, Wong Tien-Yin, Li Xiang, Hamzah Haslina, Aung Tin, Su Daniel Hsien-Wen
Singapore Eye Research Institute, Singapore, Singapore.
Graefes Arch Clin Exp Ophthalmol. 2015 Apr;253(4):583-9. doi: 10.1007/s00417-014-2895-9. Epub 2015 Jan 21.
To compare differences in retinal arterial and venular caliber (RAC and RVC respectively) between fellow eyes with glaucoma of asymmetric severity.
We included subjects with bilateral primary glaucoma that had vertical cup-disc ratios (VCDR) >0.2 between both eyes, or visual field (VF) mean deviation (MD) >6.0 decibels (dB) between both eyes.
Among 158 subjects, the average RAC in glaucoma eyes was 131.5 ± 17.8 μm vs 141.6 ± 18.8 μm in fellow eyes with mild disease (p < 0.001). RVCs in glaucoma eyes were 201.0 ± 21.4 μm vs 211.7 ± 25.3 μm in fellow eyes with mild disease (p < 0.001). This relationship held in clustered linear regression models adjusted for age, gender, vascular risk factors, visual acuity, axial length, and intraocular pressure, with RVCs narrower in eyes with worse disease vs mild disease. Eyes with worse disease had greater VCDR (0.9 ± 0.1 vs 0.7 ± 0.1, p < 0.001), and worse VF MD (-18.5 ± 8.6 vs -6.6 ± 5.6, p < 0.001).
In glaucoma with asymmetric severity between fellow eyes, retinal vascular caliber is less in the eye with more severe disease.
比较病情严重程度不对称的青光眼患者患眼与对侧眼之间视网膜动脉和静脉管径（分别为RAC和RVC）的差异。
我们纳入了双眼原发性青光眼患者，其双眼垂直杯盘比（VCDR）>0.2，或双眼视野（VF）平均偏差（MD）>6.0分贝（dB）。
在158名受试者中，青光眼患眼的平均RAC为131.5±17.8μm，而病情较轻的对侧眼为141.6±18.8μm（p<0.001）。青光眼患眼的RVC为201.0±21.4μm，而病情较轻的对侧眼为211.7±25.3μm（p<0.001）。在对年龄、性别、血管危险因素、视力、眼轴长度和眼压进行校正的聚类线性回归模型中，这种关系依然成立，病情较重的患眼RVC比病情较轻的患眼更窄。病情较重的患眼VCDR更大（0.9±0.1对0.7±0.1，p<0.001），VF MD更差（-18.5±8.6对-6.6±5.6，p<0.001）。
在双眼病情严重程度不对称的青光眼患者中，病情较重的患眼视网膜血管管径更小。
