Respiratory Diseases Department of Nanlou, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China.
Respiratory Diseases Department of Nanlou, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China; National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Chang Bai Road, Changping District, Beijing 102206, China.
Int J Antimicrob Agents. 2015 May;45(5):491-5. doi: 10.1016/j.ijantimicag.2015.01.012. Epub 2015 Mar 1.
The aim of this study was to investigate the differences in risk factors and drug susceptibility between Mycobacterium avium and Mycobacterium intracellulare lung diseases in China. In total, 452 nontuberculous mycobacteria (NTM) strains isolated from patients with NTM lung diseases in four specialised TB hospitals were enrolled in this study. The minimum inhibitory concentration (MIC) was used to evaluate the drug susceptibility of M. avium and M. intracellulare isolates. In addition, demographic and clinical characteristics of patients with NTM lung diseases caused by M. avium and M. intracellulare were analysed. Of 452 NTM isolates, M. intracellulare (188; 41.6%) was the most frequently isolated organism. The percentages of moxifloxacin- and linezolid-resistant strains among the M. intracellulare isolates were significantly lower than those among the M. avium group (P=0.003 and P<0.001, respectively). In contrast, M. avium harboured a lower proportion of rifampicin-resistant strains than M. intracellulare (P=0.005). Among patients with M. intracellulare lung diseases, the percentages of patients aged >64 years and patients with chronic obstructive pulmonary disease (COPD) were significantly higher than among patients with M. avium (P=0.008 for age and P=0.001 for COPD). In conclusion, these data demonstrated that M. intracellulare was the most common NTM species in China. This study also revealed that M. intracellulare and M. avium differed in their drug susceptibility profiles. In addition, clinical cases of M. intracellulare lung diseases were more likely to be found in the aged population and among patients with COPD co-morbidity.
本研究旨在探讨中国鸟分枝杆菌和胞内分枝杆菌肺病的危险因素和药物敏感性差异。本研究共纳入 4 家结核病专科医院分枝杆菌肺病患者分离的 452 株非结核分枝杆菌（NTM）。采用最低抑菌浓度（MIC）评估鸟分枝杆菌和胞内分枝杆菌分离株的药物敏感性。此外，分析了鸟分枝杆菌和胞内分枝杆菌肺病患者的人口统计学和临床特征。在 452 株 NTM 分离株中，胞内分枝杆菌（188 株；41.6%）是最常分离的菌株。与鸟分枝杆菌组相比，胞内分枝杆菌分离株中莫西沙星和利奈唑胺耐药株的比例明显较低（P=0.003 和 P<0.001）。相比之下，鸟分枝杆菌携带利福平耐药株的比例低于胞内分枝杆菌（P=0.005）。在胞内分枝杆菌肺病患者中，年龄>64 岁和慢性阻塞性肺疾病（COPD）患者的比例明显高于鸟分枝杆菌患者（P=0.008 年龄和 P=0.001 COPD）。总之，这些数据表明胞内分枝杆菌是中国最常见的 NTM 物种。本研究还表明，胞内分枝杆菌和鸟分枝杆菌在药物敏感性谱上存在差异。此外，胞内分枝杆菌肺病的临床病例更可能发生在老年人群和 COPD 合并症患者中。
