Wang Yiting, Zheng Huiwen, Wang Xijiang, Wang Xinqi, Liu Nianqiang, Wang Le, Liu Zhenjiang, Meng Xiangli, Abullimiti Maiweilanjiang, Aihemuti Maimaitiaili, Huang Fang, Huang Fei, Ou Xichao, Wang Senlu, Zhao Yanlin
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Institute for Immunization and Prevention, Beijing Key Laboratory of Surveillance, Early Warning and Pathogen Research on Emerging Infectious Diseases, Beijing Center for Disease Prevention and Control, Beijing 100013, China; Beijing Research Center for Respiratory Infectious Diseases, Beijing 100013, China; School of Public Health, Capital Medical University, Beijing, 100017, China.
Curr Microbiol. 2025 Jul 11;82(9):376. doi: 10.1007/s00284-025-04357-0.
To investigate the prevalent characteristic of nontuberculous mycobacteria (NTM) isolates in Kashgar. A total of 52 NTM culture-positive isolates were collected in 2020 from Kashgar, China. All strains were confirmed to be NTM species by whole genome sequencing (WGS). Drug susceptibility testing was performed using Sensititre SLOMYCO plates. Of the 52 NTM isolates, 88.46% (46/52) were rapidly growing mycobacteria (RGM). The predominant NTM species were Mycolicibacterium. sp (23.07%, 12/52) and M. elephantis (15.38%, 8/52), followed by Mycobacteroides chelonae (9.61%, 5/52). At least, two suspected new species were identified. Two core virulence genes were identified in more than 95% of the isolates. Antimicrobial susceptibility testing revealed high resistance among RGM isolates to imipenem (73.91%), while remained sensitive to amikacin and ciprofloxacin. All slowly growing mycobacteria isolates exhibited the highest resistance rate against doxycycline (83.3%, 5/6), but most strains were sensitive to clarithromycin, rifabutin, amikacin, ciprofloxacin, moxifloxacin, rifampin, and trimethoprim-sulfamethoxazole. The prevalence of NTM isolates in Kashgar presents a very specific features and some rarely reported species constitute big proportions. Amikacin and moxifloxacin may represent effective therapeutic options for NTM infections in Kashgar.
为调查喀什地区非结核分枝杆菌（NTM）分离株的流行特征。2020年从中国喀什共收集了52株NTM培养阳性分离株。所有菌株均通过全基因组测序（WGS）确认为NTM菌种。使用Sensititre SLOMYCO平板进行药敏试验。在52株NTM分离株中，88.46%（46/52）为快速生长分枝杆菌（RGM）。主要的NTM菌种为Mycolicibacterium. sp（23.07%，12/52）和象分枝杆菌（15.38%，8/52），其次是龟分枝杆菌（9.61%，5/52）。至少鉴定出两个疑似新菌种。在超过95%的分离株中鉴定出两个核心毒力基因。药敏试验显示，RGM分离株对亚胺培南的耐药率较高（73.91%），而对阿米卡星和环丙沙星仍敏感。所有缓慢生长分枝杆菌分离株对多西环素的耐药率最高（83.3%，5/6），但大多数菌株对克拉霉素、利福布汀、阿米卡星、环丙沙星、莫西沙星、利福平以及复方新诺明敏感。喀什地区NTM分离株的流行呈现出非常特殊的特征，一些罕见报道的菌种占比很大。阿米卡星和莫西沙星可能是喀什地区NTM感染的有效治疗选择。
