M'Buyamba-Kabangu J R, Lijnen P, Fagard R, Groeseneken D, Koninckx P, Lissens W, Van Assche F, Amery A
Am J Obstet Gynecol. 1985 Mar 1;151(5):687-93. doi: 10.1016/0002-9378(85)90166-8.
The erythrocyte concentrations and the transmembrane fluxes of sodium and potassium were investigated in 20 normal women during the two stages of the menstrual cycle. Half of the women were using oral contraceptives and the other half were not. In women with a normal menstrual cycle the erythrocyte sodium concentration and the ouabain-insensitive total potassium efflux were lower in the luteal than in the follicular phase. Intracellular potassium concentration, ouabain-sensitive rubidium 86 uptake and the furosemide-sensitive sodium and potassium efflux did not differ significantly between the two periods of the cycle. No cycle-related variation in sodium or potassium intracellular concentration was observed in women using oral contraceptives. In these women, however, the ouabain-sensitive 86Rb uptake was increased in the second part of the menstrual cycle. In each woman with a normal menstrual cycle the plasma progesterone, renin activity, angiotensin II, plasma aldosterone concentration, and urinary aldosterone excretion increased during the luteal phase. The increment in the plasma renin activity, plasma angiotensin II, and plasma and urinary aldosterone indicate a stimulation of the renin-aldosterone axis in this menstrual period. During the same phase, serum cholesterol was decreased significantly. When the women using oral contraceptives were compared to those not using them, the renin-aldosterone axis was already stimulated during the first part of the cycle; no further stimulation occurred during the second part.
在月经周期的两个阶段，对20名正常女性的红细胞浓度以及钠和钾的跨膜通量进行了研究。其中一半女性使用口服避孕药，另一半未使用。在月经周期正常的女性中，黄体期的红细胞钠浓度和哇巴因不敏感的总钾外流低于卵泡期。细胞内钾浓度、哇巴因敏感的铷86摄取以及速尿敏感的钠和钾外流在月经周期的两个阶段之间没有显著差异。使用口服避孕药的女性未观察到钠或钾细胞内浓度与月经周期相关的变化。然而，在这些女性中，月经周期第二阶段哇巴因敏感的86Rb摄取增加。在每个月经周期正常的女性中，黄体期血浆孕酮、肾素活性、血管紧张素II、血浆醛固酮浓度和尿醛固酮排泄均增加。血浆肾素活性、血浆血管紧张素II以及血浆和尿醛固酮的增加表明该月经期肾素-醛固酮轴受到刺激。在同一阶段，血清胆固醇显著降低。将使用口服避孕药的女性与未使用的女性进行比较时，肾素-醛固酮轴在月经周期的第一阶段就已经受到刺激；在第二阶段没有进一步的刺激。
